Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

doi:10.5500/wjt.v14.i3.94914

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Transplant. Sep 18, 2024; 14(3): 94914
Published online Sep 18, 2024. doi: 10.5500/wjt.v14.i3.94914

Table 6 Univariate and multivariate analysis for the endpoint of hepatocellular carcinoma related mortality

Variables	Univariate analysis		Multivariate analysis
Variables	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Sex	0.87 (95%CI: 0.20-3.84)	0.86	0.90 (95%CI: 0.23-3.56)	0.88
Age at LT	1.02 (95%CI: 0.93-1.12)	0.68	1.05 (95%CI: 0.94-1.17)	0.36
Aetiology of liver disease
HBV	1.19 (95%CI: 0.34-4.21)	0.78
HCV	1.41 (95%CI: 0.41-4.21)	0.57
NAFLD	0.80 (95%CI: 0.16-3.90)	0.78
Statin use	0.46 (95%CI: 0.059-3.53)	0.45	0.32 (95%CI: 0.033-3.09)	0.32
Aspirin use	0.50 (95%CI: 0.10-2.40)	0.39	0.71 (95%CI: 0.14-3.73)	0.69
Metformin use	1.27 (95%CI: 0.36-4.49)	0.71	1.57 (95%CI: 0.61-4.04)	0.35
Statins, aspirin or metformin use¹	0.67 (95%CI: 0.21-2.08)	0.48	0.61 (95%CI: 0.18-2.08)	0.43
MTORi use	0.96 (95%CI: 0.35-2.65)	0.93	0.63 (95%CI: 0.26-1.49)	0.29
Pre LT co-morbidities
Diabetes	0.62 (95%CI: 0.11-3.51)	0.59
Stroke	N/A
Hypertension	0.29 (95%CI: 0.06-1.47)	0.14
Obesity	0.35 (95%CI: 0.10-1.15)	0.08	0.23 (95%CI: 0.06-0.85)	0.027
Ischaemic heart disease	N/A	N/A
Total cholesterol mmol/L	0.77 (95%CI: 0.17-3.45)	0.74
Other variables
Microvascular invasion	7.52 (95%CI: 2.22-25.47)	< 0.01	8.05 (95%CI: 2.63-24.68)	< 0.01
AFP > 100 ng/mL immediately pre-LT	2.83 (95%CI: 0.85-9.44)	0.09	3.11 (95%CI: 0.70-13.76)	0.14
Pre-LT regional treatments ≥ 3	1.58 (95%CI: 0.45-5.52)	0.48
Pre-LT size of largest lesion ≥ 3 cm	2.19 (95%CI: 0.60-7.96)	0.23
Beyond Milan	2.72 (95%CI: 0.80-9.30)	0.11
Beyond up-to-7	5.29 (95%CI: 1.55-18.13)	< 0.01	4.14 (95%CI: 1.09-15.81)	0.038
Complete response at LT	0.32 (95%CI: 0.055-1.88)	0.21

¹Multivariate analysis performed separately with the composite variable of statins, aspirin or metformin use included a priori.

N/A indicates numbers insufficient to calculate hazard ratio and P value. Hypertension: Systolic blood pressure > 140 mmHg. HBV: Hepatitis B virus; HCV: Hepatitis C virus; NAFLD: Non-alcoholic fatty liver disease; AFP: Alfa-fetoprotein; BMI: Body mass index; LT: Liver transplantation.

Citation: Chung W, Wong K, Ravindranayagam N, Tang L, Grace J, Wong D, Con D, Sinclair M, Majumdar A, Kutaiba N, Hui S, Gow P, Muralidharan V, Dobrovic A, Testro A. Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study. World J Transplant 2024; 14(3): 94914
URL: https://www.wjgnet.com/2220-3230/full/v14/i3/94914.htm
DOI: https://dx.doi.org/10.5500/wjt.v14.i3.94914