Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

Table 1 Summary patient characteristics

	n	%
Patients	305
Sex (Male)	253	82.95
Age at LT [median (Q1-3)]	58.90 (53.8-63)
Aetiology of liver disease
HBV	73	23.93
HCV	150	49.18
Alcohol related liver disease	86	28.20
NAFLD	33	10.82
Co-morbidities prior to LT
Diabetes	96	31.48
Hypertension	73	23.93
Stroke	6	1.97
Obesity (BMI > 30)	103	33.77
Total cholesterol ≥ 4 mmol/L	253	82.95
AFP ≥ 100 ng/mL	26	8.52
Regional therapy ≥ 3	140	45.90
Largest diameter of HCC ≥ 3 cm	97	31.80
Histology
Microvascular invasion	40	13.11
Beyond Milan criteria	90	29.51
Beyond Up-to-7 criteria	52	17.05
Complete response at LT	107	35.08
Follow up time [median months (Q1-Q3)]	59.90 (27.93-99.61)
HCC-recurrence (overall)	34	11.15
HCC-recurrence after 24 months	16	5.25
All-cause mortality	48	15.74
Composite endpoint of HCC-recurrence or all-cause mortality	65	21.31
HCC-related mortality	17	5.57

LT: Liver transplantation; HBV: Hepatitis B virus; HCV: Hepatitis C virus; NAFLD: Non-alcoholic fatty liver disease; AFP: Alfa-fetoprotein; BMI: Body mass index; HCC: Hepatocellular carcinoma.