Recipient functional status impacts on short and long-term intestinal transplant outcomes in United States adults

Table 2 Comparison of patient outcomes by functional status categories, n (%)/mean ± SD

	Functional status at transplant
	Requires no assistance (n = 251)	Requires some assistance (n = 648)	Near death or severely disabled (n = 355)	Total (n = 1254)	P value
Gender					0.0341
Female	130 (51.8)	368 (56.8)	172 (48.5)	670 (53.4)
Male	121 (48.2)	280 (43.2)	183 (51.5)	584 (46.6)
Age (Year)					0.222
n	251	648	355	1254
Mean (SD)	40.9 (14.18)	42.7 (13.04)	42.1 (12.79)	42.1 (13.21)
Median	41.0	44.0	42.0	43.0
Range	18.0-73.0	18.0-72.0	18.0-70.0	18.0-73.0
Race					0.791
Hispanic	22 (8.8)	49 (7.6)	31 (8.7)	102 (8.1)
Non-Hispanic Asian	3 (1.2)	11 (1.7)	5 (1.4)	19 (1.5)
Non-Hispanic Black	29 (11.6)	71 (11.0)	43 (12.1)	143 (11.4)
Non-Hispanic White	194 (77.3)	515 (79.5)	275 (77.5)	984 (78.5)
Other/Multiracial	3 (1.2)	2 (0.3)	1 (0.3)	6 (0.5)
Patients on life support					0.00402
No	242 (96.4)	602 (92.9)	317 (89.3)	1161 (92.6)
Yes	9 (3.6)	46 (7.1)	38 (10.7)	93 (7.4)
Sex match					0.161
No	125 (49.8)	288 (44.4)	177 (49.9)	590 (47.0)
Yes	126 (50.2)	360 (55.6)	178 (50.1)	664 (53.0)
Recipient total bilirubin at transplantation (mg/dL)					0.00062
n	249	644	354	1247
Mean (SD)	2.2 (5.36)	2.3 (4.57)	4.6 (8.44)	2.9 (6.15)
Median	0.8	0.8	1.1	0.9
Range	0.1-50.0	0.1-43.0	0.1-48.2	0.1-50.0
Serum creatinine at time of transplantation (mg/dL)					0.361
n	251	645	353	1249
Mean (SD)	1.0 (0.72)	1.1 (0.96)	1.2 (1.04)	1.1 (0.94)
Median	0.9	0.9	0.9	0.9
Range	0.3-7.6	0.3-10.1	0.1-9.0	0.1-10.1
Total ischemic time (sec)					0.0102
n	222	619	347	1188
Mean (SD)	6.9 (1.88)	7.5 (2.32)	7.5 (2.28)	7.4 (2.24)
Median	7.0	7.3	7.4	7.2
Range	1.0-11.8	0.4-31.5	0.9-31.7	0.4-31.7
Recipient's primary diagnosis					0.010411
Short gut syndrome	154 (19.8)	409 (52.5)	216 (27.7)	779 (62.1)
Functional bowel problem	27 (28.1)	51 (53.1)	18 (18.8)	96 (7.7)
Retransplant	4 (6.2)	39 (60.9)	21 (32.8)	64 (5.1)
Others	66 (21.0)	149 (47.3)	100 (31.7)	315 (25.1)
Donor age (years)					0.362
n	251	648	355	1254
Mean (SD)	22.4 (10.79)	21.1 (10.54)	21.3 (11.47)	21.4 (10.86)
Median	20.0	19.0	20.0	19.0
Range	4.0-56.0	2.0-52.0	1.0-59.0	1.0-59.0
Race match					0.431
No	119 (47.4)	278 (42.9)	152 (42.8)	549 (43.8)
Yes	132 (52.6)	370 (57.1)	203 (57.2)	705 (56.2)
Weight mismatch					0.00691
NA	4 (1.6)	7 (1.1)	0 (0.0)	11 (0.9)
No mismatch	170 (67.7)	397 (61.3)	201 (56.6)	768 (61.2)
Weight mismatch	77 (30.7)	244 (37.7)	154 (43.4)	475 (37.9)
History of diabetes					0.0821
Diabetes	21 (8.4)	68 (10.5)	49 (13.9)	138 (11.0)
Not diabetes	230 (91.6)	580 (89.5)	303 (86.1)	1113 (89.0)
Liver function					< 0.00011
Liver dysfunction	62 (24.9)	148 (23.0)	126 (35.6)	336 (26.9)
No dysfunction	187 (75.1)	496 (77.0)	228 (64.4)	911 (73.1)
Renal function					0.0381
No dysfunction	244 (97.2)	617 (95.7)	328 (92.9)	1189 (95.2)
Renal dysfunction	7 (2.8)	28 (4.3)	25 (7.1)	60 (4.8)
HLA mismatch					0.201
High HLA mismatch	208 (87.0)	522 (82.6)	293 (85.7)	1023 (84.3)
Low HLA mismatch	31 (13.0)	110 (17.4)	49 (14.3)	190 (15.7)
Recipient's weight (kg)					0.0572
n	247	641	355	1243
Mean (SD)	68.0 (17.35)	66.8 (17.16)	69.2 (17.83)	67.7 (17.41)
Median	65.8	64.0	66.8	65.1
Range	34.0-130.0	36.3-140.1	27.4-122.0	27.4-140.1
Calculated body mass index of recipients (kg/m2)					0.282
n	246	635	355	1236
Mean (SD)	23.9 (5.25)	23.4 (4.83)	23.9 (5.28)	23.7 (5.05)
Median	23.2	22.8	23.0	23.0
Range	15.0-40.6	15.1-41.9	15.1-44.2	15.0-44.2

¹Chi-Square P-value.

²Kruskal-Wallis P-value.

HLA: Human leukocyte antigen.