Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

Table 2 Association between donor, recipients, and surgical procedures with the development of early allograft dysfunction, n (%)

	All patients (n = 228)	With EAD (n = 57)	Without EAD (n = 171)	P value
Donors’ characteristics
Age (yr)	41 ± 14	43 ± 14	40 ± 14	0.186
BMI (kg/m2)	25.5 ± 3.6	26 ± 4.1	25.3 ± 3.5	0.286
Need for vasopressors	187 (82)	44 (77.2)	143 (8.6)	0.273
Time on MV before donation (d)	4 (3-7)	5 (4-11)	4 (3-7)	0.001
Cardiac arrest	41 (18)	14 (24.6)	27 (15.8)	0.135
DRI score	1.3 (1.1-1.6)	1.3 (1.1-1.5)	1.4 (1.1-1.7)	0.224
Recipients’ characteristics
Age (yr)	56 ± 11	53 ± 13	58 ± 10	0.021
BMI (kg/m2)	27.7 ± 4.8	28.9 ± 5.9	27.4 ± 4.1	0.112
Indication for transplantation				0.079
Alcoholic liver disease	62 (27.2)	13 (22.8)	49 (28.7)
Viral hepatitis	74 (32.4)	16 (28.1)	58 (33.9)
Non-alcoholic steatohepatitis	26 (11.4)	8 (14)	18 (10.5)
Cryptogenic	21 (9.2)	4 (7.0)	17 (9.9)
Others	45 (19.7)	16 (28.1)	29 (17)
MELD score	19 (14-24)	20 (13-25)	18 (12-23)	0.047
Biochemistry at ICU admission
Albumin (g/dL)	2.6 (2.3-2.9)	2.5 (2.3-1.7)	2.7 (2.3-2.9)	0.314
Creatinine (mg/dL)	0.9 (0.7-1.2)	0.9 (0.7-1.3)	0.8 (0.7-1.1)	0.009
Platelets (10³/mm³)	105 (67-142)	104 (74-143)	108 (82-157)	0.057
AST (U/L)	1055 (580-1829)	1370 (739-3174)	1003 (561-1434)	< 0.001
ALT (U/L)	611 (375-1041)	799 (435-1583)	488 (289-826)	< 0.001
INR	2.1 (1.7-2.7)	2.7 (1.9-3.7)	2.1 (1.7-2.7)	< 0.001
Bilirubin (mg/dL)	4 (2.3-6.2)	6.5 (4.1-8.8)	3.7 (2.5-5.3)	0.077
Surgical procedures
Donor hepatectomy time (min)	29 (23-40)	30 (23-39)		0.126
Cold ischemia time (min)	405 (329-492)	388 (311-495)	407 (334-483)	0.291
Warm ischemia time (min)	34 (30-37)	35 (30-39)	34 (3037)	0.079

Values are mean ± SD or median and interquartile range. Student's t test, Mann-Whitney U test or χ² test was used as appropriate. P value was considered significant at P < 0.05. AD: Early allograft dysfunction; BMI: Body mass index; MV: Mechanical ventilation; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; MELD: Model of end-stage liver disease; DRI: Donor Risk Index; ICU: Intensive care unit; INR: International normalized ratio.