Liver transplantation for hepatocellular carcinoma in India: Are we ready for 2040?

Table 3 Different criteria for liver transplantation in hepatocellular carcinoma patients

Criteria name (yr)	Size of tumor (cm)	No. of tumors	Additional criteria	Overall 5-year survival
Milan criteria (1996)	≤ 5; ≤ 3	1; 3	None	75%
UCSF criteria (2001)	6.5; ≤ 4.5 (total ≤ 8)	1; 3	None	75.2%
Up-to-7 criteria (2001)	Size (cm) + No. ≤ 7		None
Navarro criteria (2001)	≤ 6; ≤ 5	1; 3	None	79%
Tokyo criteria (2007)	≤ 5	≤ 5	None	75%
Asan criteria (2008)	≤ 5	≤ 6	None	82%
Hangzhou criteria (2008)	< 8 (total)	Any No.	AFP < 400 ng/mL	72%
Chang Gung criteria (2008)	≤ 6.5; ≤ 4.5	1; ≤ 3	None	90%
Hong Kong criteria (2008)	≤ 6.5; ≤ 4.5	1; ≤ 3	None	66%
Kyushu criteria (2009)	≤ 5	Any No.	PIVKA-II < 300 mAU/mL	83%
Kyoto criteria (2010)	≤ 5	≤ 10	PIVKA-II < 400 mAU/mL	87%
Toronto criteria (2011)	Any Size	Any No.	Poorly differentiated HCC excluded	72%
Japanese National Expanded criteria (2019)	≤ 5	≤ 5	AFP < 500 ng/mL	75.8%

All the criteria exclude any vascular invasion or any extra-hepatic spread[25-33]. HCC: Hepatocellular carcinoma.