Reasons and effects of the decline of willing related potential living kidney donors

Table 4 Patients distributed per characteristics of exclusion of their potential living donors presented as total patients (n = 212) and as a comparison between patients with candidate (n = 74) and patients with non-candidate (n = 138) potential living donors.

Characteristics	Total patients, n = 212	Patients with candidate PLDs, n = 74	Patients with non-candidate PLDs, n = 138	P value
	mean ± SD (range)/number (%)
Patients per number of excluded PLDs, n = 121
Patients with one excluded PLD	100 (82.6%)	10 (71.4%)	90 (84.1%)	0.764
Patients with two excluded PLDs	19 (15.7%)	4 (28.6%)	15 (14.0%)
Patients with three excluded PLDs	2 (1.7%)	0 (0%)	2 (1.9%)
Patients per causes of exclusion of their PLDs, n = 1211
Combined immunological and medical causes	14 (11.6%)	3 (21.4%)	11 (10.3%)	0.680
HLA-incompatibility	24 (19.8%)	3 (21.4%)	21 (19.6%)
ABO-incompatibility	20 (16.5%)	1 (7.1%)	19 (17.8%)
ABO and HLA-incompatibility	2 (1.7%)	0 (0%)	2 (1.9%)
Age	8 (6.6%)	0 (0%)	8 (7.5%)
Diabetes mellitus	4 (3.3%)	0 (0%)	4 (3.7%)
HCV positive	5 (4.1%)	2 (14.3%)	3 (2.8%)
Hypertension	11 (9.1%)	4 (28.6%)	7 (6.5%)
Leprosy	1 (0.8%)	0 (0%)	1 (0.9%)
Low GFR	4 (3.3%)	1 (7.1%)	3 (2.8%)
High potential recurrence of primary kidney disease	6 (5.0%)	0 (0%)	6 (5.6%)
Proteinuria	12 (9.9%)	0 (0%)	12 (11.2%)
Psoriasis	1 (0.8%)	0 (0%)	1 (0.9%)
Rheumatoid arthritis	1 (0.8%)	0 (0%)	1 (0.9%)
Urolithiasis	5 (4.1%)	0 (0%)	5 (4.7%)
Financial causes	3 (2.5%)	0 (0%)	3 (2.8%)
Patients per main category of causes of exclusion of their PLDs, n = 121
Combined immunological and medical causes	14 (11.6%)	3 (21.4%)	11 (10.3%)	0.866
Immunologic mismatches	46 (38%)	4 (28.6%)	42 (39.3%)
Medical causes	58 (47.9%)	7 (50.0%)	51 (47.7%)
Financial causes	3 (2.5%)	0 (0%)	3 (2.8%)
Patients per timing of PLDs regression, n = 18
During evaluation	13 (72.2%)	0 (0%)	13 (100.0%)	NA
After evaluation	5 (27.8%)	5 (100.0%)	0 (0%)
Patients per cause of release of PLDs, n = 37
Patient death	4 (10.8%)	3 (27.3%)	1 (3.9%)	0.186
Patient regression	22 (59.5%)	6 (54.5%)	16 (61.5%)
Patient non-candidacy	11 (29.7%)	2 (18.2%)	9 (34.6%)
Patients per timing of release of PLDs, n = 37
During evaluation	26 (70.3%)	0 (0%)	26 (100.0%)	NA
After evaluation	11 (29.7%)	11 (100.0%)	0 (0%)
Fate of patients with evaluated PLDs, n = 212
Transplantation in our center	58 (27.4%)	58 (78.4%)	0 (0%)	NA
Transplantation in another center	14 (6.6%)	1 (1.4%)	13 (9.4%)	0.024
On hemodialysis	122 (57.6%)	12 (16.2%)	110 (79.7%)	< 0.001
Death	9 (4.2%)	3 (4.1%)	6 (4.4%)	0.920
Unknown	9 (4.2%)	0 (0%)	9 (6.5%)	0.024

¹Regarding the exclusion due to anatomical abnormalities, they included ectopic pelvic kidney, solitary kidney, and hypoplastic kidney in 3 patients. They were included in donors with a low split glomerular filtration rate. However, kidneys with unilateral simple cysts in 2 patients and three renal arteries in 2 patients were not the cause of exclusion. In the former, the cysts were treated by marsupialization after perfusion and before implantation in the recipients. In the latter, the contralateral kidneys were donated. GFR: Glomerular filtration rate; HCV: Hepatitis C virus; HLA: Human leukocytic antigen; NA: Not available; PLD: Potential living donor; SD: Standard deviation.