Invasive aspergillosis in liver transplant recipients, an infectious complication with low incidence but significant mortality

Table 4 Comparison of the post-transplant factors in the study population

Covariate	Case	Control	P value	OR (95%CI)
Antifungal prophylaxis after transplant (Fluconazole)	10 (45.5%)	13 (34.2%)	0.003	0.20 (0.05-0.85)
Antifungal prophylaxis after transplant (voriconazole)	9 (40.9%)	5 (13.1%)		0.08 (0.02-0.43)
Antifungal prophylaxis after transplant (no)	3 (13.6%)	20 (52.7%)		-
Bacteremia within 2 wk before diagnosis	3 (13.6%)	4 (10.5%)	0.70	-
Pneumonia within 2 wk before diagnosis	13 (59.1%)	4 (10.5%)	< 0.001	0.08 (0.02-0.31)
Systemic antibacterial within 2 wk before diagnosis	16 (72.7%)	15 (39.5%)	< 0.001	4.09 (1.31-12.81)
Dialysis requirement	7 (31.8%)	4 (10.5%)	0.08
CMV viremia before diagnosis	9 (40.9%)	4 (10.5%)	0.009	5.89 (1.54-22.47)
CMV diseases before diagnosis	3 (13.6%)	2 (5.3%)	0.35
Length of ICU stay at the time of transplant	4.05 (3.59)	1.75 (1.20)	0.008	0.56 (0.38-0.82)
Duration of mechanical ventilation at the time of transplant	1.25 (0.55)	1.12 (0.41)	0.34
Creatinine at the day of diagnosis (highest value)	1/87 (SD:1/1)	1/21 (SD:1/43)	-	-

CI: Confidence interval; CMV: Cytomegalovirus; ICU: Intensive care unit; OR: Odds ratio; SD: Standard deviation.