Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation

Table 2 Tacrolimus intra-patient variability in lung transplantation: main findings

Lung transplantation
Ref.	Sample size	Donor type	Tac-IPV assessment	Outcome
Gallagher et al[28], 2015	110	Non specified	SD	Patients with highly variable trough tacrolimus levels in the second half of the first post-transplant year will likely have similar variability in the second year and are at high risk for subsequent chronic lung allograft dysfunction and death
Kao et al[29], 2021	157	Non specified	CV and TTR	The results suggest that tacrolimus TTR, time in therapeutic range, and variability are not related to the presence of ACR in LTRs
Ensor et al[30], 2018	292	Non specified	TTR	Tacrolimus TTR was predictive of clinical outcomes of ACR, CLAD, infection, and death in lung transplant recipients at 1 yr in this investigation after adjusting for potential confounders
Katada et al[31], 2022	90	Living and deceased	TTR	A lower tacrolimus TTR is a predictor of late acute rejection

SD: Standard deviation; TTR: Time in therapeutic range; ACR: Acute cellular rejection; LTR: Lung transplant rejection; CLAD: Chronic lung allograft dysfunction.