Delayed referral for liver transplant evaluation worsens outcomes in chronic liver disease patients requiring inpatient transplant evaluation

Table 2 Liver transplant evaluation data, %

	Delayed	Early	P value
Transferred to center	48.7	51.2	0.75
MELD-Na (points)	27.2 (7)	27.0 (9)	0.87
TIPS placed	15.4	7.3	0.22
ICU stay	51.3	43.9	0.35
ICU d (#)	10 (9)	8 (7)	0.44
Pressor support	34.6	26.8	0.29
Declined for LT listing	17.9	15.9	0.72
Reasons declined
Psychosocial	30.0	12.5	0.38
Medical	20.0	25.0
Death	30.0	12.5
Other	20.0	50.0
Decompensations
Ascites	94.9	96.3	0.65
Jaundice	64.1	72.0	0.29
EVB	21.8	24.4	0.70
HE	70.7	70.5	0.98
HRS	59.8	62.8	0.69
HHT	21.8	14.6	0.24
SBP	21.8	18.3	0.58
ACLF grade
Grade 1	34.6	42.7	0.56
Grade 2	50.0	42.7
Grade 3	15.4	14.6
ACLF bilirubin
< 15 mg/dL	82.1	76.8	0.28
15-25 mg/dL	9.0	17.1
> 25 mg/dL	9.0	6.1
ACLF INR
< 1.8	62.8	62.2	0.78
1.8-2.5	28.2	25.6
> 2.5	9	12.2
ACLF lactate
< 1.5 mmol/L	73.1	80.5	0.16
1.5-2.5 mmol/L	15.4	6.1
> 2.5 mmol/L	11.5	13.4
ACLF creatinine
< 0.7 mg/dL	7.3	7.3	0.64
0.7-1.5 mg/dL	32.9	32.9
> 1.5 mg/dL	52.6	59.8

Clinical data from index admission and liver transplant evaluation. Data reported as percentages of group for categorical data; as average (standard deviation) for normally distributed continuous data. Comparisons were made using students T tests and comparison of proportions test. ACLF: Acute on chronic liver failure; LT: Liver transplant; ICU: Intensive care unit; MELD: Model for end stage liver disease; TIPS: Trans-jugular intrahepatic portosystemic shunt; EVB: Esophagogastric variceal bleeding; HRS: Hepatorenal syndrome; HHT: Hepatic hydrothorax; SBP: Spontaneous bacterial peritonitis; LTE: Liver transplant evaluation; INR: International normalized ratio; HE: Hepatic encephalopathy.