Is peri-transplant blood transfusion associated with worse transplant outcomes? A retrospective study

Table 5 Characteristics of rejection developers vs non-rejection developers among the study cohort, n (%)

	Non-rejection, 100	Rejection, 5	P value
Age (mean ± SD)	36.5 (28.25-51.75)	36 (21-46.5)	0.383
Gender
Female	28 (28)	0 (0)	0.321
Male	72 (72)	5 (100)
Type of transplantation
LRKTx	81 (81)	3 (60)	0.172
LURKTx	13 (13)	2 (40)
DDKTx	6 (6)	0 (0)
HLA mismatch	3 (1-4)	3 (1-4)	0.729
Cause of ESRD
Diabetes	18 (18)	0 (0)	0.199
GN	23 (23)	3 (60)
Hypertension	18 (18)	0 (0)
PCKD	1 (1)	0 (0)
Urological	6 (6)	1 (20)
Other	34 (34)	1 (20)
Donor's age	32 (26-39)	28 (25.5-43.5)	0.981
Induction therapy
ATG	41 (41)	1 (20)	0.438
Basiliximab	58 (58)	4 (80)
No induction	1 (1)	0 (0)
Average CNI level	7 (6-8)	8 (6.5-9)	0.311
Hb at transplantation	10.65 (9.025-11.3)	10.7 (9.05-12.45)	0.792
Hb at blood transfusion	7.4 (6.8-8)	7.81	0.138
Hb after transfusion	8.9 (8.4-10)	101	0.382
No of blood transfusion unites given	1 (0-1)	1 (0-3)	0.491
Serum creatinine
At discharge	111 (83.25-142.75)	151 (113.5-222.5)	0.096
6 mo	102.5 (80.5-123)	120 (80-156)	0.420
12 mo	99.5 (81.75-119.25)	124.5 (92.5-140.75)	0.201
18 mo	105 (84.25-119)	107 (72-)	0.894
Death	1 (1)	1 (20)	0.093
DGF	9 (9)	2 (40)	0.084
No. of infections	0 (0-1)	1 (0-2)	0.651
Types of infections
None	53 (53)	2 (40)	0.188
UTI	30 (28.6)	29 (29)	1
Pnemonia	1 (1)	1 (1)	1
TB	1 (1)	1 (1)	1
BK	7 (6.7)	7 (7)	1
Bactremia	4 (3.8)	4 (4)	1
Epidediymo-orchitis	2 (1.9)	2 (2)	1
Gastroenteritis	2 (1.9)	1 (1)	0.093
Herpes zoster	1 (1)	1 (1)	1
Infected AVF	1 (1)	1 (1)	1
Perianal abcess	1 (1)	1 (1)	1
COVID-19	9 (8.6)	8 (8)	0.367
URTI	2 (1.9)	1 (1)	0.093
CMV	11 (11)	1 (20)	0.462
Urological complications
None	90 (90)	5 (100)	1
Allograft artery stenosis	1 (1)	0 (0)
Collection	3 (3)	0 (0)
Lymphocele	1 (1)	0 (0)
Obstrctive uropathy	1 (1)	0 (0)
Perinephric collection and ureteric stricture	2 (2)	0 (0)
Unrogenic bladder	1 (1)	0 (0)
Urinary leak	1 (1)	0 (0)
Urological complications
No	90 (90)	5 (100)	1
Yes	10 (10)	0 (0)

¹Interquartile range could not be calculated due to small number of patients for this outcome.

COVID-19: Coronavirus disease 2019; LRKTX: Living-related kidney transplantation; LURKTx: Living non-related kidney transplantation; DDKTX: Deceased-donor kidney transplantation; HLA: Human leucocyte antigen; ESRD: End-stage renal disease; GN: Glomerulonephritis; PCKD: polycystic kidney disease; ATG: Antithymocyte globulin; CNI: Calcineurin inhibitor; MMF: Mycophenolate mofetil; Hb: Hemoglobin; DGF: Delayed-graft function; UTI: Urinary tract infection; TB: Tuberculosis; AVF: Arterio-venous fistula; URTI: Upper respiratory tract infection; CMV: Cytomegalovirus.