Analysis of the effects of donor and recipient hepatitis C infection on kidney transplant outcomes in the United States

Table 3 Characteristics of transplantation in the pre-direct-acting antivirals era and the post-direct-acting antivirals era

Characteristics		D-R-	D-R+	D+R-	D+R+	P value
n	Pre	116108	4646	550	2455
	Post	46099	1443	1082	1303
TX year (median [IQR])	Pre	2005 [2000, 2010]	2004 [1999, 2009]	2001 [1997, 2007]	2006 [2001, 2010]	< 0.001
	Post	2016 [2015, 2018]	2016 [2015, 2018]	2018 [2017, 2018]	2016 [2015, 2017]	< 0.001
Region (%)
1	Pre	4694 (4.0)	167 (3.6)	11 (2.0)	74 (3.0)	< 0.001
2		14123 (12.2)	661 (14.2)	112 (20.4)	823 (33.5)
3		17507 (15.1)	704 (15.2)	64 (11.6)	235 (9.6)
4		10816 (9.3)	414 (8.9)	29 (5.3)	136 (5.5)
5		17680 (15.2)	655 (14.1)	63 (11.5)	260 (10.6)
6		4356 (3.8)	156 (3.4)	6 (1.1)	7 (0.3)
7		9360 (8.1)	403 (8.7)	54 (9.8)	137 (5.6)
8		7738 (6.7)	252 (5.4)	23 (4.2)	55 (2.2)
9		7150 (6.2)	355 (7.6)	29 (5.3)	222 (9.0)
10		10186 (8.8)	457 (9.8)	104 (18.9)	192 (7.8)
11		12498 (10.8)	422 (9.1)	55 (10.0)	314 (12.8)
1	Post	1601 (3.5)	62 (4.3)	35 (3.2)	65 (5.0)	< 0.001
2		5404 (11.7)	182 (12.6)	151 (14.0)	349 (26.8)
3		6590 (14.3)	221 (15.3)	181 (16.7)	150 (11.5)
4		4526 (9.8)	173 (12.0)	45 (4.2)	67 (5.1)
5		8107 (17.6)	238 (16.5)	101 (9.3)	144 (11.1)
6		1911 (4.1)	55 (3.8)	13 (1.2)	6 (0.5)
7		3192 (6.9)	110 (7.6)	37 (3.4)	45 (3.5)
8		3130 (6.8)	86 (6.0)	5 (0.5)	44 (3.4)
9		3057 (6.6)	85 (5.9)	125 (11.6)	174 (13.4)
10		3507 (7.6)	79 (5.5)	195 (18.0)	84 (6.4)
11		5074 (11.0)	152 (10.5)	194 (17.9)	175 (13.4)
Shared (%)
Local	Pre	85197 (73.4)	3464 (74.6)	223 (40.5)	931 (37.9)	< 0.001
Regional		9559 (8.2)	377 (8.1)	124 (22.5)	591 (24.1)
National		21352 (18.4)	805 (17.3)	203 (36.9)	933 (38.0)
Local	Post	35095 (76.1)	1115 (77.3)	337 (31.1)	379 (29.1)	< 0.001
Regional		5349 (11.6)	157 (10.9)	345 (31.9)	348 (26.7)
National		5655 (12.3)	171 (11.9)	400 (37.0)	576 (44.2)
CIT (median [IQR])	Pre	18.0 [13.0, 23.1]	18.0 [13.0, 23.5]	20.0 [16.0, 26.0]	19.0 [15.0, 25.0]	< 0.001
	Post	16.7 [11.4, 22.6]	16.5 [11.0, 22.0]	18.4 [13.1, 23.8]	18.0 [12.3, 23.5]	< 0.001
HLA mismatch = 4-6 (%)	Pre	76253 (65.7)	3238 (69.7)	452 (82.2)	2151 (87.6)	< 0.001
	Post	35126 (76.2)	1170 (81.1)	894 (82.6)	1154 (88.6)	< 0.001
DGF = yes (%)	Pre	28919 (24.9)	1440 (31.0)	139 (25.3)	756 (30.8)	< 0.001
	Post	13468 (29.2)	496 (34.4)	222 (20.5)	284 (21.8)	< 0.001

D(-/+) R(-/+), hepatitis C virus (-) or (+) donors into hepatitis C virus (-) or (+) recipients. CIT: Cold ischemia time; DGF: Delayed graft function; HLA: Human leukocyte antigen; IQR: Interquartile range; Pre: Pre-direct-acting antivirals era; Post: Post-direct-acting antivirals era; TX: Transplantation.