Analysis of the effects of donor and recipient hepatitis C infection on kidney transplant outcomes in the United States

Table 2 Characteristics of recipients in the pre-direct-acting antivirals era and the post-direct-acting antivirals era

Characteristics		D-R-	D-R+	D+R-	D+R+	P value
n	Pre	116108	4646	550	2455
	Post	46099	1443	1082	1303
Age (median [IQR])	Pre	53.0 [42.0, 61.0]	51.0 [44.0, 58.0]	57.0 [47.0, 65.0]	53.0 [47.0, 59.0]	< 0.001
	Post	55.0 [44.0, 64.0]	59.0 [52.0, 64.0]	60.0 [52.0, 67.0]	60.0 [55.5, 65.0]	< 0.001
Gender = M (%)	Pre	69448 (59.8)	3251 (70.0)	406 (73.8)	1995 (81.3)	< 0.001
	Post	27135 (58.9)	994 (68.9)	739 (68.3)	1017 (78.1)	< 0.001
BMI (median [IQR])	Pre	26.8 [23.6, 30.9]	26.1 [23.0, 29.9]	26.5 [23.6, 29.4]	26.4 [23.3, 29.8]	< 0.001
	Post	28.6 [24.9, 32.8]	27.8 [24.4, 31.6]	29.1 [25.7, 33.3]	27.8 [24.5, 31.5]	< 0.001
Race (%)
White	Pre	56376 (48.6)	1383 (29.8)	211 (38.4)	404 (16.5)	< 0.001
African American		34683 (29.9)	2447 (52.7)	290 (52.7)	1789 (72.9)
Hispanic		15940 (13.7)	517 (11.1)	27 (4.9)	201 (8.2)
Other		9109 (7.8)	299 (6.4)	22 (4.0)	61 (2.5)
White	Post	16501 (35.8)	334 (23.1)	494 (45.7)	267 (20.5)	< 0.001
African American		15762 (34.2)	784 (54.3)	392 (36.2)	855 (65.6)
Hispanic		9079 (19.7)	226 (15.7)	117 (10.8)	137 (10.5)
Other		4757 (10.3)	99 (6.9)	79 (7.3)	44 (3.4)
Insurance = nonprivate (%)	Pre	83051 (71.5)	3733 (80.3)	418 (76.0)	1831 (74.6)	< 0.001
	Post	37085 (80.4)	1265 (87.7)	831 (76.8)	993 (76.2)	< 0.001
Education level (%)
High school	Pre	44906 (38.7)	1923 (41.4)	222 (40.4)	1195 (48.7)	< 0.001
Technical		22531 (19.4)	931 (20.0)	86 (15.6)	450 (18.3)
Post high school degree		18972 (16.3)	494 (10.6)	59 (10.7)	254 (10.3)
High school	Post	19085 (41.4)	741 (51.4)	403 (37.2)	680 (52.2)	< 0.001
Technical		11577 (25.1)	369 (25.6)	280 (25.9)	318 (24.4)
Post high school degree		10687 (23.2)	230 (15.9)	331 (30.6)	214 (16.4)
ESRD (%)
Diabetes	Pre	32208 (27.7)	1193 (25.7)	178 (32.4)	783 (31.9)	< 0.001
Hypertension		30368 (26.2)	1745 (37.6)	221 (40.2)	1108 (45.1)
Other		53532 (46.1)	1708 (36.8)	151 (27.5)	564 (23.0)
Diabetes	Post	14439 (31.3)	477 (33.1)	438 (40.5)	601 (46.1)	< 0.001
Hypertension		12513 (27.1)	543 (37.6)	270 (25.0)	444 (34.1)
Other		19147 (41.5)	423 (29.3)	374 (34.6)	258 (19.8)
Dialysis time, day, (median [IQR])	Pre	1143 [708, 1691]	1344 [889, 2164]	976 [580, 1388]	1118 [603, 1596]	< 0.001
	Post	1661 [1043, 2373]	1999 [1364, 2988]	1257 [637, 1674]	1065 [593, 1661]	< 0.001
CPRA (median [IQR])	Pre	0.0 [0.0, 2.0]	0.0 [0.0, 2.0]	0.0 [0.0, 0.0]	0.0 [0.0, 0.0]	< 0.001
CPRA (mean [SD])	Post	19.3 (32.8)	20.5 (33.5)	9.4 (21.9)	9.3 (21.3)	< 0.001
PVD = yes (%)	Pre	5374 (4.6)	210 (4.5)	26 (4.7)	111 (4.5)	< 0.001
	Post	4590 (10.0)	186 (12.9)	118 (10.9)	148 (11.4)	0.001
Diabetes = yes (%)	Pre	38827 (33.4)	1491 (32.1)	225 (40.9)	1014 (41.3)	< 0.001
	Post	17213 (37.3)	583 (40.4)	521 (48.2)	714 (54.8)	< 0.001

D(-/+) R(-/+), hepatitis C virus (-) or (+) donors into hepatitis C virus (-) or (+) recipients. BMI: Body mass index; ESRD: End stage renal disease; IQR: Interquartile range; M: Male; Pre: Pre-direct-acting antivirals era; Post: Post-direct-acting antivirals era; CPRA: Calculated panel reaction antibody; PVD: Peripheral vascular disease.