Kidney disease in non-kidney solid organ transplantation

Table 5 Kidney disease after intestinal

Ref.	Total number of patients, n	Risk factors associated with kidney disease	Study conclusion
Huard et al[48]	843	Female sex (HR = 1.34), older age (HR = 1.38/10 yr increment), catheter-related sepsis (HR = 1.58), steroid maintenance immunosuppression (HR = 1.50), graft failure (HR = 1.76), ACR (HR = 1.64), prolonged requirement for IV fluids (HR = 2.12) or TPN (HR = 1.94), and diabetes (HR = 1.54)	Cumulative incidence of severe CKD of 3.2%, 25.1%, and 54.1% 1, 5 and 10 yr after intestinal transplant; in adjusted analysis, severe CKD was associated with a significantly higher hazard of death (HR = 6.20)
Herlenius et al[76]	10		In the adult patients, GFR 3 mo post transplantation had decreased to 50% of the baseline. At 1 yr, median GFR in the adult patients was reduced by 72% (n = 5). Two patients developed renal failure within the first year and required hemodialysis
Ueno et al[49]	24	Cumulative tacrolimus levels > 4500ng ng∙day/mL associated with significantly decreased creatinine clearance at 2 yr (P = 0.006)	Post-transplant mean creatinine clearance was significantly lower at 2 yr compared to baseline (49.6 mL/min/1.73 m2vs 114 mL/min/1.73 m2, P < 0.0001)

HR: Hazard ratio; ACR: Acute cellular rejection; TPN: Total parenteral nutrition; CKD: Chronic kidney disease; GFR: Glomerular filtration rate.