Liver transplantation in acute liver failure: Dilemmas and challenges

Table 3 Factors associated with poor outcomes of liver transplantation in acute liver failure patients

Ref.	Country	Patients	Determinant of poor outcomes
Barshes et al[67], 2006	United States	n = 1457	Body mass index > or = 30 kg/m2. Serum creatinine > 2.0 mg/Dl. Recipient age > 50 years old. History of life support.
Bernal et al[56], 2009	United Kingdom	n = 310	Age > 45 years old. Vasopressor requirement. Transplantation before 2000. Use of high-risk grafts.
Park et al[88], 2010	South Korea	n = 44	Older age. Higher MELD.
Germani et al[6], 2012	Europe	n = 4903	Recipient > 50 yr. Incompatible ABO matching. Donors > 60 yr. Reduced size graft.
Yuan et al[58], 2012	China	n = 20	Pre-transplant waiting time > 5 d.
Yamashiki et al[77], 2012	Japan	n = 209	Older age of recipient and donor. Incompatible ABO.
Hoyer et al[89], 2014	Germany	n = 57	Lowest pH of the recipient before LT. PH ≤ 7.26 have the worst outcome.
Pamecha et al[90], 2019	India	n = 61	Postoperative worsening of cerebral edema. Systemic inflammatory response syndrome. Preoperative culture positivity. Longer duration of anhepatic phase.

LT: Liver transplantation; MELD: Model for end stage liver disease; ABO: Arquivos brasileiros de oftalmologia.