Review
Copyright ©The Author(s) 2020.
World J Transplant. Jul 29, 2020; 10(7): 191-205
Published online Jul 29, 2020. doi: 10.5500/wjt.v10.i7.191
Table 2 Meta-analysis of 4810 ABO incompatibility kidney transplants, grade evidence profile of studies for patient and graft survival after preconditioning therapies[40]
Risk of bias/quality of evidenceConsistencyDirectnessPrecisionPublication biasOverall survival probabilityQuality of evidence
Apheresis: 21 (12 cohort studies; 1 case-control; 8 case series)No serious risk of bias; lack RCTsSome inconsistencyDirectNo serious imprecisionSuspected publication biasPatient survival 93.5%Very low
Immunoadsorption: 4 (3 cohort studies; 1 case series)No serious risk of bias; Lack of RCTsNo inconsistency-1No serious imprecisionNo important publication biasPatient survival 96.4%Very low
Splenectomy: 12 (9 cohort studies; 3 case series)No serious risk of bias; Lack of RCTsSome inconsistencyDirectNo serious imprecisionSuspected publication biasPatient survival 91%Very low
Rituximab: 17 (11 cohort studies; 6 case series)No serious risk of bias; Lack of RCTsNo inconsistencyDirectNo serious imprecisionSuspected publication biasPatient survival 96.2%Very low