Copyright
©The Author(s) 2020.
World J Transplant. Jun 29, 2020; 10(6): 162-172
Published online Jun 29, 2020. doi: 10.5500/wjt.v10.i6.162
Published online Jun 29, 2020. doi: 10.5500/wjt.v10.i6.162
Type of Infection | Type of organism | TLR alleles | Clinical significance |
Bacterial infections | Staph aurus | TLR2 (Arg753Gln) | Inconclusive association with septic shock |
TLR2 (R753Q) | May correlated only in cases of infections with large dose of pathogen | ||
Listeria monocytogenes | TLR2/MyD88-dependent pathway | Participate in cytokine cascade No role in clearance | |
Salmonella typhimurium | TLR4 | Granuloma formation | |
Salmonella choleraesuis | TLR2, TLR4 | Have role in pathogenesis; No role in clearance | |
TLR9 | Has role in clearance | ||
Protozoal | Plasmodium falciparum | TLR1, TLR6 | Mild form of malaria |
TLR9 (1486 C/T) | Severe form of malaria | ||
Mycobacterium | Mycobaterial tuberculosis | TLR2 (R753Q) | Increased susceptibility to T.B in Turkish |
TLR2 (Arg677Trp) | Increased susceptibility to T.B in Tunisian but not to Iranian and Indian populations. | ||
Viral | Hepatitis C virus (HCV) | TLR2 (Arg753Gln) | Recurrence of HCV post transplant (PT) with higher graft cirrhosis and graft failure |
TLR2 (R753Q) | Higher rate of graft failure | ||
TLR3 | Increased liver fibrosis | ||
TLR4 (Asp299Gly) and (Thr399Ile) | No associated PT complications | ||
TLR7/8-mediated pathway | Aggressive PT recurrence of HCV | ||
Cytomegalovirus (CMV) | TLR2 (R753Q) TLR2 (Arg753Gln) | Increased incidence of CMV PT |
- Citation: El-Bendary M, Naemattalah M, Yassen A, Mousa N, Elhammady D, Sultan AM, Abdel-Wahab M. Interrelationship between Toll-like receptors and infection after orthotopic liver transplantation. World J Transplant 2020; 10(6): 162-172
- URL: https://www.wjgnet.com/2220-3230/full/v10/i6/162.htm
- DOI: https://dx.doi.org/10.5500/wjt.v10.i6.162