Copyright
©The Author(s) 2020.
World J Transplant. May 29, 2020; 10(5): 90-103
Published online May 29, 2020. doi: 10.5500/wjt.v10.i5.90
Published online May 29, 2020. doi: 10.5500/wjt.v10.i5.90
Table 9 Association of variant ADME genes to pharmacokinetics of selected small molecule immunosuppressants[80]
| Drug | Phase I enzymes | Phase II enzymes | Uptake transporters | ABC transporters | |||
| CYP3A4 | CYP3A5 | UGT1A9 | OATP1B1/3 | ABCB1 | ABCC2 | IMPDH I/II | |
| rs35599367 | rs776746, rs10264272 | rs17868320, rs6714486 | rs41490556, rs4149117 | rs1128503, rs2032582, rs1045642 | rs717620 | rs2278293, rs2278294, rs11706052 | |
| Mycophenolic acid | - | - | + | (+) | - | (+) | + |
| Cyclosporine | (+) | - | - | - | (+) | - | - |
| Tacrolimus | + | ++ | - | - | (+) | - | - |
| Sirolimus | (+) | - | - | - | - | - | - |
- Citation: Salvadori M, Tsalouchos A. Pharmacogenetics of immunosuppressant drugs: A new aspect for individualized therapy. World J Transplant 2020; 10(5): 90-103
- URL: https://www.wjgnet.com/2220-3230/full/v10/i5/90.htm
- DOI: https://dx.doi.org/10.5500/wjt.v10.i5.90