Pharmacogenetics of immunosuppressant drugs: A new aspect for individualized therapy

Table 8 Studies documenting the association between some single-nucleotide polymorphisms and transplant outcomes[67,73,77-79]

Drug	SNPs	Patients (n)	Outcomes	OR	CI	P value
CNI	rs2069762TT	50	CAN	4.57	1.04-20.11	0.044
CNI	rs8177826	290	Nephrotoxicity	3.49	1.47-8.24	0.006
CNI	rs2069762	90	AR	6.3	1.8-22.15	0.005
EC-MPS	rs11706052	237	AR	3.39	1.42-8.09	0.006
EC-MPS	rs2278293	191	AR	0.34	0.15-0.76	0.008
EC-MPS	rs2278294	191	AR	0.40	0.18-0.89	0.02

OR: Odds ratio; CI: Confidence interval; AR: Acute rejection; SNPs: Single-nucleotide polymorphisms; EC-MPS: Enteric coated mycophenolate sodium.