Pharmacogenetics of immunosuppressant drugs: A new aspect for individualized therapy

Table 6 Candidate single-nucleotide polymorphisms related to the pharmacodynamics pathways of mammalian target of rapamycin inhibitors with quality of evidence of existing data and level of recommendation[6]

Drugs	Gene	SNP	MAF	QOE	LOR
mTOR inhibitors	mTOR	rs2024627	T = 0.270	A	1
		rs2295080	G = 0.308	A	1
		rs1883965	A = 0.288	B	1
		rs1057079	G = 0.243	C	3

Level of recommendation: 1: Highly recommended candidate; 2: Recommended candidate; 3: Potential candidate; 4: Candidate to exclude. SNP: Single-nucleotide polymorphism; mTORI: Mammalian target of rapamycin inhibitors; LOR: Level of recommendation; MAF: Minor allele frequency; QOE: Quality of evidence.