Pharmacogenetics of immunosuppressant drugs: A new aspect for individualized therapy

Table 4 Amount of variability in tacrolimus troughs that can be explained in African American model[39]

Model	Variation of tacrolimus troughs	Variation explained by model
Simple time-trend model	0.3114	-
Clinical variables	0.2497	19.8%
Clinical variables + rs776746	0.1929	39.1%
Clinical variables + rs10264272	0.2495	19.9%
Clinical variables + rs41303343	0.2310	25.8%
Clinical variables + rs776746 + rs10264272	0.1845	40.7%
Clinical variables + rs776746 + rs41303343	0.1553	50.1%
Clinical variables + rs776746 + rs10264272 + rs41303343	0.1436	53.9%