Novel alternative transplantation therapy for orthotopic liver transplantation in liver failure: A systematic review

doi:10.5500/wjt.v10.i3.64

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Mar 31, 2020; 10(3): 64-78
Published online Mar 31, 2020. doi: 10.5500/wjt.v10.i3.64

Table 1 Cell transplantation

Donor			*Recipients (disease, strain etc.)*	Outcomes	Year
Cells	Species	Treatments [co-culture (Co), organoid generated]	*Recipients (disease, strain etc.)*	Outcomes	Year
Hepatocytes	Human	-	Human (ALF)	Hepatic function	2018[13]
		-	Human (ACLF)	Hepatic function	2014[22]
		-	Human (metabolic disease)	Engraftment, hepatic function	2012[23]
		-	Human (oxalosis)	Hepatic function	2012[24]
		-	Rat (SD)	Hepatic function, survival extension	2017[25]
		-	Mouse (NOD/SCID)	Alb secretion, engraftment	2017[26]
		-	Mouse (FRG)	Engraftment, hepatic function	2013[27]
		-	Mouse (SCID/Alb-uPA)	Analysis of NK cell	2010[28]
		UC-MSC (human)	Mouse (BALB/c)	Engraftment, hepatic function	2018[29]
	Rat	-	Mouse (C57BL/6 FRG)		2018[30]
		-	Rat (Wistar)	Engraftment	2015[31]
		-	Rat (SD)	Engraftment, hepatic function	2015[32]
		-	Rat	Engraftment	2014[33]
		-	Rat (DPP4-)	Engraftment, repopulation	2014[34]
		-	Rat (An alb)	Engraftment, hepatic function	2014[35]
		HSCs (Rat), SECs (Rat)/Co	Mouse (C57BL/6)	Engraftment, survival extension	2014[36]
		-	Rat (SD)	Hepatic function	2010[37]
	Mouse	Organoid	Mouse (C57BL/6)	Engraftment	2017[38]
		-	Mouse (emdr2^−/−)	Engraftment, Repopulation	2015[39]
		-	Mouse (Fah-/-)	Hepatic function	2010[40]
		-	Mouse (FVB/N)	Engraftment, analysis of metabolite	2010[41]
		-	Mouse (C57BL/6)	Engraftment	2010[42]
Hepatocytes (fetal)	Rat	-	Rat (DPPIV^-)	Engraftment, repopulation	2018[43]
Hepatocytes (fetal)	Mouse	-	Mouse (C57BL/6)	Engraftment, hepatic function	2012[44]
Liver cells	Rabbit	-	Rabbit (New Zealand)	Hepatic function	2012[45]
Hepatic oval cells	Rat	-	Rat (Lewis)	Hepatic function, survival extension	2013[46]
Hepatoma cell line		-	Rat (SD)	Hepatic function, survival extension	2013[47]
UC-MSCs	Human	-	Human after OLT	Hepatic function, intervention rate	2017[48]
UC-MSCs	Human	-	Human after OLT	Hepatic function	2017[49]
BM-MSCs/BM-MNCs	Human	-	Human (LC)	Hepatic function	2017[50]
		-			2016[51]
		-	Human (Liver failure)	Hepatic function	2013[52]
	Rabbit	-	Rabbit	Remodeling	2011[53]
BM-MSCs/HSCs	Human	-	Human (EPP)	Engraftment	2010[54]
BM-MSC	Human	-	Human (LC)	Engraftment, hepatic function	2011[55]
		-	Rat (Wistar)	Hepatic function	2014[56]
		-	Mouse (SCID)	Engraftment, analysis of glucose	2017[57]
		-	Mouse (Pfp/Rag2^−/−)	Engraftment	2010[58]
	Rhesus macaque	-	Mouse	Hepatic function	2018[59]
	Rat	-	Rat (SD)	Hepatic function	2014[60]
BM-MNC-EPC	Rat	-	Rat (SD)	Remodeling	2012[61]
Liver-MSCs	Human	-	Mouse (NOD/SCID)	Engraftment, repopulation	2011[62]
AD-MSCs	Human	-	Mouse (c57/B6)	Analysis of IRI	2014[63]
AD-MSCs	Mouse	-	Mouse (Swiss CD1)	Repopulation	2012[64]
AD-MSC-Hep	Mouse	-	Mouse (C57BL/6)	Engraftment	2015[65]
CD34+ cells	Human	-	Human (LC)	Hepatic function	2015[66]
ESCs-Hep	Mouse	-	Mouse (BALB/c)	Engraftment, hepatic function	2012[67]
iPSC-Hep	Human	Organoid	Mouse (Alb-Tk-NOG)	Survival extension, hepatic function	2017[68]
	Human	Organoid	Mouse (NOD/SCID)	Engraftment	2013[69]
	Mouse	-	Mouse (Fah-/- C57Bl/6)	Engraftment	2010[70]
iMPC-Hep	Human	-	Mouse (FRG)	Engraftment	2014[71]
GPSCs-Hep	Mouse	-	Mouse (Hfe-null)	Engraftment	2015[72]
Liver stem cells	Rat	Organoid	Rat (Fah^−/−Il2rg^−/−)	Engraftment, hepatic function	2016[73]

“-” means negative treatment. ALF: Acute liver failure; ACLF: Acute on chronic liver failure; SD: Sprague dawley; UC-MSCs: Umbilical cord deriver mesenchymal stem cells; BM-MSCs: Bone marrow derived mesenchymal stem cells; MNCs: Mononuclear cells; HSCs: Hematopoietic stem cells; LC: Liver cirrhosis; EPP: Erythropoietic protoporphyria; BM-MNC-EPC: BM-MNC derived endothelial progenitor cell; AD-MSCs: Adipose derived MSCs; IRI: Ischemia-reperfusion injury; AD-MSC-Hep: AD-MSC derived hepatocyte; iMPC: Induced multipotent progenitor cell; GPSCs: Germ line cell-derived pluripotent stem cells.

Citation: Furuta T, Furuya K, Zheng YW, Oda T. Novel alternative transplantation therapy for orthotopic liver transplantation in liver failure: A systematic review. World J Transplant 2020; 10(3): 64-78
URL: https://www.wjgnet.com/2220-3230/full/v10/i3/64.htm
DOI: https://dx.doi.org/10.5500/wjt.v10.i3.64