Machine perfusion in abdominal organ transplantation: Current use in the Netherlands

Table 4 Currently ongoing clinical trials concerning ex vivo machine perfusion in kidney transplantation

Name of study	Registration number	Design	PI	n	Primary outcome	Intervention	Included donors	Results
Unknown	ISRCTN91315246	Non-randomized	Cambridge	90	Graft function	1 h NMP	Discarded kidneys	November 2019
COPE-POMP	ISRCTN63852508	RCT	COPE Essen	262	Graft survival 1y	Short period HMP vs SCS only	ECD-DBD	July 2019
COPE-COMPARE	ISRCTN32967929	RCT	COPE Leuven	162	Kidney graft function 1 y	HMP with oxygen vs HMP without oxygen	DCD III	↓ risk BPAR ↑ 1-y eGFR[44]
PIO	NCT03031067	Case control	Bologna	20	Graft function	2 h HMP vs SCS	ECD -DBD	February 2018
PREDICTION	NCT02055950	Case control	Bergamo	60	Kidney function	HMP vs SCS	ECD-DBD	Augustus 2018
Unknown	NCT03837197	RCT	Bologna	260	DGF	2 h oxygenated HMP vs SCS	ECD-DBD	December 2021
IMPULSION	NCT01170910	RCT	Lyon	162	DGF	6-8 h HMP vs SCS	ECD	August 2016
Machine perfusion trial	ISRCTN83876362	RCT	COPE Groningen	654	DGF	Non-oxygenated HMP vs SCS	DCD III and DBD	↓ risk of DGF (OR 0.57) ↓ risk of graft failure (HR 0.52) ↑ allograft survival (94 vs 90%, P = 0.04)[27]
Unknown	ISRCTN15821205	RCT	Cambridge	400	DGF	1 h pre-transplant NMP vs SCS	DCD III and IV	January 2021

BPAR: Biopsy proven acute rejection; COPE: Consortium for Organ Preservation in Europe; DBD: Donation after brain death; DCD: Donation after circulatory death; DGF: Delayed graft function; ECD: Expanded criteria donor; eGFR: Estimated glomerular filtration rate; HMP: Hypothermic machine perfusion; HR: Hazard ratio; NMP: Normothermic machine perfusion; OR: Odds ratio; PI: Principal investigator; RCT: Randomized controlled trial; SCS: Static cold storage.