Therapeutics administered during ex vivo liver machine perfusion: An overview

doi:10.5500/wjt.v10.i1.1

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Jan 18, 2020 (publication date) through Jul 28, 2024

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jan 18, 2020; 10(1): 1-14
Published online Jan 18, 2020. doi: 10.5500/wjt.v10.i1.1

Table 1 Major categories of ex vivo machine perfusion therapeutics in liver transplantation

Category	Agents
RNAi pathway	siRNA
RNAi pathway	Anti-sense oligonucleotide (Miravirsen)
Defatting cocktail	Variable
Vasodilators	Prostacyclin
	BQ123 and Verapamil
	Prostaglandin E1
Others	Anti-inflammatory agents
	Human liver stem cells extracellular vesicles
	δ-opioid agonist (Enkephalin)
	NLRP3 inflammasome inhibitor mcc950

RNAi: Ribonucleic acid interference; siRNA: Small interfering ribonucleic acid; NLRP3: Nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3.

Citation: Buchwald JE, Xu J, Bozorgzadeh A, Martins PN. Therapeutics administered during ex vivo liver machine perfusion: An overview. World J Transplant 2020; 10(1): 1-14
URL: https://www.wjgnet.com/2220-3230/full/v10/i1/1.htm
DOI: https://dx.doi.org/10.5500/wjt.v10.i1.1