Physicians’ knowledge and attitude regarding bisphosphonates-related adverse events: An observational study

Table 1 Bisphosphonates-reported side effects, characteristics, and rating

Side effects	BPs incriminated	Causality link	Rating of correct answers	Rating of false answers
Upper GI intolerance	Oral amino-BPs	Established	2	0
Acute phase reaction	IV amino-BPs	Established	2	0
Hypocalcaemia	IV > oral BPs	Established	2	0
Renal toxicity	Zoledronate and pamidronate	Established	2	0
Severe musculoskeletal pain	Oral BPs	Probable	1	0
Ocular inflammation	All BPs	Probable	1	0
Atypical femoral fractures	BPs treatment for osteoporosis	Probable	1	0
Osteonecrosis of the jaw	IV BPs treatment in oncology	Probable	1	0
Atrial fibrillation	---	Unproven	1	-1
Esophageal cancer	---	Unproven	1	-1
Hepatotoxicity	---	Unproven	1	-1

BPs: Bisphosphonates; GI: Gastrointestinal; IV: Intravenous.