What is the best biological treatment for rheumatoid arthritis? A systematic review of effectiveness

doi:10.5499/wjr.v5.i2.108

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World Journal of Rheumatology

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2220-3214

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Rheumatol. Jul 12, 2015; 5(2): 108-126
Published online Jul 12, 2015. doi: 10.5499/wjr.v5.i2.108

Table 7 Meta-analysis of the outcomes for patients in treatment with biological monotherapy vs biological in combination with methotrexate

Intervention	Outcomes	Studies (references)	Participants	Relative risk (95%CI) or other mesure	I²(%)	P value
bDMARD monotherapy vs bDMARD + MTX	EULAR good response	3 (16,17, 30)	3000	0.57 [0.34-0.95]	82	0.0008
	DAS 28	3 (17, 20, 30)	2913	0.25 [-0.02-0.52]	69	0.01
	HAQ	2 (165, 30)	655	0.13 [0.03-0.22]	0	0.43

A value of I² > 40% indicates statistical heterogeneity between the studies. A value of P < 0.10 from the χ² test indicates statistical heterogeneity between the studies. CI: Confidence interval; bDMARD: Biological disease-modifying antirheumatic drugs; MTX: Methotrexate; EULAR: European League Against Rheumatism; DAS 28: Disease activity score; HAQ: Health Assessment Questionnaire.

Citation: Santos JBD, Costa JO, Junior HAO, Lemos LLP, Araújo VE, Machado MA&, Almeida AM, Acurcio FA, Alvares J. What is the best biological treatment for rheumatoid arthritis? A systematic review of effectiveness. World J Rheumatol 2015; 5(2): 108-126
URL: https://www.wjgnet.com/2220-3214/full/v5/i2/108.htm
DOI: https://dx.doi.org/10.5499/wjr.v5.i2.108