Oral creatine supplementation: A potential adjunct therapy for rheumatoid arthritis patients

Table 1 Summary of the results from the meta-analysis by Nissen et al[37]

Supplement(n = studies)	Average dosage (maintenance dose)	Duration(wk)	Net leanmass change	Net strength change
Cr (n = 18)	19.4 g/d for 5.3 d (6.7 g/d)	7.5	+0.36%/wkb	+1.09%/wkb
HMB (n = 9)	3 g/d	8	+0.28%/wkb	+1.40%/wkb
Chromium (n = 12)	485 μg/d	11.2	+0.08%/wk	+0.25%/wk
Androstenedione (n = 3)	200 mg/d	10.7	+0.05%/wk	-0.06%/wk
Protein (n = 4)	1.15 g/kg per day	6.3	+0.12%/wk	-0.18%/wk
DHEA (n = 2)	125 mg/d	10	+0.12%/wk	+0.06%/wk

The net change is expressed as % change per week. Only Cr and HMB resulted in significant changes;

^bP < 0.005. Cr: Creatine; HMB: β-hydroxy-β-methylbutyrate; DHEA: Dehydroepiandrosterone.