Emerging pharmacological strategies for the treatment of fibromyalgia

Table 3 Novel drugs in clinical trials for potential treatment of fibromyalgia

Drug	Mechanisms of action	Domains	Trial Sponsor	Ref.
EMA401	Angiotensin 2 receptor antagonist	Pain	Novartis/Spiniflex	[53]
Flupirtine	Potassium channel activation	Pain	Not available	[54]
Mirogabalin (DS-5565)	α2δ ligand	Pain	Daiichi Sankyo	[55]
Suvorexant	Orexin receptor antagonist	Sleep, insomnia, pain	Henry Ford Health System	[56]
Yokukansan	Herbal medication; glutamatergic and serotonergic systems	Insomnia, sleep	St Marianna University, school of Medicine	[57]
ZYN001	Cannabinoid	Pain, quality of life	Zynerba	[58]

Sources of information, MEDLINE (PubMed), ClinicalTrials.gov, adisinsight.springer.com and Controlled-trials.com.