Novel strategies for the treatment of diabetic macular edema

Table 1 Major clinical trials performed to study biologics, steroids and implants for diabetic macular edema treatment

Trade name	Generic name	Study	Main conclusion	Ref.
Lucentis	Ranibizumab	RISE/RIDE	Ranibizumab improved vision and macular edema in DME patients	[82]
Eylea	Aflibercept	VISTA/VIVID	Intravitreal injection of aflibercept was shown to be superior compared to laser therapy in treatment of DME	[91]
Ozurdex	Dexamethasone implant	MEAD	Dexamethasone implant were well tolerated and improved BCVA in DME patients	[168]
Iluvien	Fluocinolone acetonide	FAME	Both low and high dose of Fluocinolone acetonide exhibited improved BCVA in treatment of DME	[169]

DME: Diabetic macular edema; BCVA: Best corrected visual acquit.