Copyright
©The Author(s) 2015.
World J Pharmacol. Sep 9, 2015; 4(3): 236-264
Published online Sep 9, 2015. doi: 10.5497/wjp.v4.i3.236
Published online Sep 9, 2015. doi: 10.5497/wjp.v4.i3.236
Figure 2 Schematic representation indicating interlinks among important Alzheimer’s disease pathogenetic hypotheses that majorly include amyloid cascade hypothesis, taupathy, mitochondrial dysfunction hypothesis, cholesterol induced mechanism, insulin signal downregulation, calpain-cathepsin hypothesis.
APP: Amyloid precursor protein; PS: Presinilin; APoE: Apolipoprotein E; PI3K: Phosphoinositide-3-kinase; AKT: Protein kinase B; ROS: Reactive oxygen species.
- Citation: Desai P, Shete H, Adnaik R, Disouza J, Patravale V. Therapeutic targets and delivery challenges for Alzheimer’s disease. World J Pharmacol 2015; 4(3): 236-264
- URL: https://www.wjgnet.com/2220-3192/full/v4/i3/236.htm
- DOI: https://dx.doi.org/10.5497/wjp.v4.i3.236