Appropriate prescribing in the elderly: Current perspectives

doi:10.5497/wjp.v4.i2.193

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Jun 9, 2015 (publication date) through Jul 27, 2024

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World Journal of Pharmacology

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2220-3192

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Pharmacol. Jun 9, 2015; 4(2): 193-209
Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.193

Table 4 Age-associated changes in pharmacodynamic response to commonly prescribed drugs

Drug type	Specific drug	Pharmacodynamic response in older people	Potential clinical consequence
Analgesia	Morphine	↑	Excessive sedation, confusion, constipation, respiratory depression
Anticoagulant	Warfarin Dabigatran in those ≥ 75 yr with a body weight of < 50 kg)	↑	Increased bleeding risk
Cardiovascular system drugs	Angiotensin II receptor blockers	↑	Hypotension
	Diltiazem	↑
	Enalapril	↑
	Verapamil	↑
	Propranolol	↓
Diuretics	Frusemide	↓	Reduced diuretic effect at standard doses
Diuretics	Bumetanide	↑	Reduced diuretic effect at standard doses
Psychoactive drugs	Diazepam	↑	Excessive sedation, confusion, postural sway, falls
	Midazolam	↑
	Temazepam	↑
	Haloperidol	↑
	Traizolam	↑
Others	Levodopamine	↑	Dyskinesia, confusion, hallucinations

↑: Increased pharmacodynamic response; ↓: Reduced pharmacodynamic response.

Citation: Lavan AH, O’Grady J, Gallagher PF. Appropriate prescribing in the elderly: Current perspectives. World J Pharmacol 2015; 4(2): 193-209
URL: https://www.wjgnet.com/2220-3192/full/v4/i2/193.htm
DOI: https://dx.doi.org/10.5497/wjp.v4.i2.193