Carbapenemases: A worldwide threat to antimicrobial therapy

Table 3 Breakpoint and screening cut-off for carbapenemase-producing Enterobacteriaceae

	MIC (mg/L)				Disk-diffusion zone diameter (mm) using 10μg disks
	S breakpoint		Screening cut-off		S breakpoint		Screening cut-off
	EUCAST	CLSI	EUCAST	CLSI	EUCAST	CLSI	EUCAST	CLSI
Meropenem	≤ 2	≤ 1	> 0.12	2-4	≥ 22	≥ 23	< 25	16-21
Imipenem	≤ 2	≤ 1	> 1	2-4	≥ 22	≥ 23	< 23	-
Ertapenem	≤ 0.5	≤ 0.5	> 0.12	2-4	≥ 25	≥ 22	< 25	19-21

S: Susceptibility; MIC: Minimum inhibitory concentration; CLSI: Clinical Laboratory Standards Institute; EUCAST: European Committee on Antimicrobial Susceptibility Testing.