Levomilnacipran and vortioxetine: Review of new pharmacotherapies for major depressive disorder

Table 1 Basic drug information for levomilnacipran and vortioxetine[3,20]

	Levomilnacipran	Vortioxetine
Brand names	Fetzima	Brintellix
Mechanism of action	Serotonin-norepinephrine reuptake inhibitor	Serotonin receptor reuptake inhibitor, serotonin-3 receptor antagonist and serotonin-1A receptor agonist
FDA approval date	July 26, 2013	September 30, 2013
Recommended dosing range	40 mg to 120 mg once daily with or without food	10 mg to 20 mg once daily
Dosage form	Extended-release capsules in 20 mg, 40 mg, 80 mg and 120 mg	Immediate release tablets in 5 mg, 10 mg, 15 mg and 20 mg

FDA: Food and Drug Administration.