Patents on antivirulence therapies

Table 3 Patents concerning the inhibition of quorum sensing systems

Patent title	Description	Application date	Inventors	Publication number
Anti-inflammatory and quorum sensing inhibition compounds and methods of making and using them	This invention generally relates to novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them	2011	Gerwick William H; Gerwick Lena; Choi Huykjae; Villa Francisco A; Smith Jennifer; Rowley David C	WO2011153502 (A2)
Composition for oral use	A method for suppressing dental caries by regulating biofilm formation by the bacteria that cause dental caries instead of controlling these bacteria	2011	Tsugane Takanori; Saeki Yoji	EP2620160
Conjugates of acyl homoserine lactone and catalase a from Pseudomonas aeruginosa	The present invention relates to the acyl homoserine lactone N-3-(oxododecanoyl)-L-homoserine lactone or butyryl L-homoserine lactone and Pseudomona aeruginosa KatA protein, or an antigenic portion conjugate thereof, used to treat Pseudomona aeruginosa infections by limiting biofilm formation and inhibiting a range of quorum-sensing dependent virulence factors	2011	Kyd Jennelle M; Cooley Margaret	WO/2012/083382
Enzyme bag containing quorum quenching enzyme immobilized silica for inhibiting biofilm formation and membrane bioreactor system for water treatment system using the bag	This invention relates to an enzyme bag containing silica-immobilized enzyme for inhibiting biofilm formation. A membrane bioreactor system for water treatment using the bag is provided for stable implementation of filtering operations over a long period of time by improving the performance of operational processes	2011	Lee Chung Hak; Yang Cheon Seok; Lee Jung Kee; Han Jong Yun; Lee Chung Hak; Yang Cheon Seoket; Lee Jung Kee; Han Jong Yun	KR20120134724 (A)
Fluidizable carrier with biofilm formation-inhibiting microorganisms immobilized therein and membrane water treatment apparatus using the same	This invention relates to a biofilm formation-inhibiting microorganism immobilized fluidizable carrier in which a biofilm formation-inhibiting microorganism is fixed therein and a membrane water treatment apparatus including the same are provided to increase a membrane cleaning period	2011	Lee Chung Hak; Kim Sang Ryoung; Lee Jung Kee	KR20130034935 (A)
Methods of disrupting quorum sensing to affect microbial population cell density	The invention relates to the modulation of quorum sensing mechanisms in a microorganism for the purpose of exploiting the fermentation capabilities of the microorganism	2011	Marrs Barry; Swalla Brian M	US2011124522 (A1)
Quorum-sensing signal molecular preparation and application thereof in tobacco waste treatment	The invention relates to the field of environmental biotechnology, in particular to preparation of a quorum sensing signal molecule and application in processing tobacco waste	2011	Meizhen Wang; Hongzhen He; Huajun Feng; Xin Zheng; Dongsheng Shen; Zhenmei LV; Hang Min	CN102392051 (A)
Synthetic analogs of bacterial quorum sensors	The invention relates to synthetic analogs of bacterial quorum sensing molecules, and methods of use of these	2011	Iyer Rashi; Ganguly Kumkum; Silks Louis A	US2012071430 (A1)
System and method for reversing the antibiotic tolerance of bacterial persister cells	The present invention relates to antibiotics and, more particularly, to a system and method for decreasing the tolerance of bacterial persister cells to antibiotics	2011	Ren Dacheng; Pan Jiachuan	EP2603576
Triazole compounds as well as preparation method and application thereof	The present invention relates to triazole derivatives, the preparation method and as the autoinducer-2 (AI-2) quorum sensing inhibitors, belonging to anti-AI-2 quorum sensing type drug technology	2011	Minyong Li; Lvpei Du; Peng Zhu	CN102219753 (A)
Use of a novel alpha-proteobacteria for quorum quenching	The invention (concerning the fields of biology, molecular biology, and aquaculture) specifically relates to a new a-proteobacteria capable of degrading/V-acyl-homoserine lactones (AHLs) for control of bacterial infectious diseases and prevention of biofilm formation	2011	Otero Casal Ana María; Romero Bernardez Manuel	WO2011154585 (A1)
2-methylthiopyrrolidines and their use for modulating bacterial quorum sensing	Formula (I) compounds are disclosed and their use in inhibiting quorum sensing in bacteria is reported	2012	Malladi Venkata L; Schneper Lisa; Sobczak Adam J; Mathee Kalai; Wnuk Stanislaw F	WO/2012/174511
Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria	The report encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing and methods for inhibiting or attenuating microbial virulence, biofilm formation and drug resistance	2012	Wang Binghe; Ni Nantin; Wamg Junfeng; Lu Chung-Dar; Chou Han-Ting; Li Minyong; Zheng Shilong; Cheng Yunfeg; Peng Hanjing	EP2529793 (A2)
Construction and application of unmarked Lysobacter enzymogenes engineering strain capable of preventing plant bacteriosis	The invention (within the field of microbial genetic engineering), specifically relates to a plant bacterial disease that can prevent dissolving enzyme production strains of Bacillus unmarked engineering construction and application	2012	Liu Fengquan; Qian Guoliang	CN102943061 (A)
Furan compound and preparation method and application of furan compound	The invention relates to furan derivatives, the method of preparation and as the AI-2 quorum sensing inhibitors, are anti-AI-2 type of quorum sensing	2012	Minyong Li; Peng Zhu	CN102603683 (A)
Method for increasing output of microbial lovastatin based on quorum sensing mechanism	The invention relates to the pharmaceutical raw material fermentation industry, in particular to a method of increasing microbial production of lovastatin	2012	Li Haoming	CN102925509 (A)
Method for quickly identifying food-borne pathogen bacterial biofilm formation inhibitor	The invention relates to the field of food microbiology control technology, in particular to the rapid identification of an inhibitor of foodborne bacterial biofilm formation	2012	Wenyan Zhang; Hongmei Zhang; Zhihua Tao; Wenyuan Zhou	CN102706821 (A)
Phosphorylated and branched dihydroxy-pentane-ione analogs as quorum sensing inhibitors in bacteria	The invention provides compositions and methods for modulating quorum sensing in microbes and can be used in prophylactic methods or therapy for bacterial infections and for reduction of biofilms. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing	2012	Sintim Herman; Bentley William E; Roy Yarnika; Smith Jacqueline	US2012294900 (A1)
Preparation method of imprinted polymer of bacterial quorum sensing signal molecule AI-1	The present invention relates to bacterial quorum sensing signal molecules A1-1 imprinted polymer preparation	2012	Xin Li; Ling Wang	CN102604010 (A)
Probiotics for biological control against Vibrio sp.	The invention relates to probiotics for biological control against Vibrio sp., and in particular, to a newly isolated bacillus strain that degrades quorum-sensing signal molecules of the pathogenic bacteria Vibrio sp., and inhibits biofilm formation	2012	Yang Si Yong; Woo Seo Hyung; Kang In Hye; Im Hyun Jung	WO2012105805
Quorum sensing inhibitor against a pathogenic microorganism, and an antibacterial composition using the same	A quorum sensing inhibitor and an antibacterial composition using the same are provided to suppress quorum sensing between bacteria, and to prevent or treat infection or diseases	2012	Undescribed	KR101243696
Shewanella piezotolerans 34# and application thereof to algae inhibition	The invention relates to the field of biotechnology, in particular to a marine bacterium Shewanella and the inhibition of algal growth	2012	Zhou Jin; Yin Peng	CN103173383 (A)
Simple method for testing disease resistance of pathogenic bacteria quorum-quenching gene prokaryotic expression product	The invention relates to a prokaryotic expression product of disease resistance testing methods, in particular to test pathogen populations prokaryotic expression product quenching effect of a simple disease, and belongs to the field of gene function identification techniques	2012	Ouyang Lejun; Huang Zhenchi; Zeng Fuhua; Li Limei; Li Heng	CN102972220 (A)
Use of quorum sensing inhibitors and biofilm dispersing agents for controlling biofilm-associated implantable medical device related infections	The invention generally relates to implantable medical devices and, more specifically, to the use of quorum sensing inhibitors and/or biofilm dispersing agents to control biofilm-associated infections related to the use of implantable medical devices	2012	Samade Richard; Dinesh Prashant; Nabutovsky Yelena; Bornzin Gene A; Poore John W; Karicherla Annapurna; Dalal Nirav	US2014005605 (A1)
Bacillus pumillus microbial preparation with quorum sensing system inhibiting effect	The invention relates to Bacillus pumillus with a quorum sensing system inhibiting effect. The invention has the advantages that Chromobacterium violaceum is used for screening out a bacterial strain F3-1. It can be used to produce a microbial preparation capable of preventing and treating aquatic bacterial diseases	2013	Song Zengfu; Fan Bin; Chen Biao	CN103525723 (A)
Bicyclic furanones with low toxicity for microbial control	The invention relates to a class of bicyclic brominated furanone structures with reduced toxicity and high activity for inhibiting biofilm formation and quorum sensing by microbes	2013	Luk Yan-Yeung; Yang Sijie	US2013197077 (A1)
Method for detecting quorum sensing quenching bacterial strain	The invention relates to a method for detecting a quorum sensing quenching bacterial strain. The method comprises the addition of a bacterial strain to be detected in a PIPES (1,4-piperazinediethanesulfonic acid) buffer solution of pH 6	2013	Zhang Xiaohua; Tang Kaihao; Shi Xiaochong; Zhang Yunhui	CN103215342 (A)
Quorum-quenching enzyme OLB-26, and coding gene and application thereof	The invention relates to a quorum sensing quenching enzyme 0LB-26 and its coding gene and application	2013	Zhou Zhigang; Zhang Meichao; Yang Yalin; Xu Li; He Suxu; Li Qing; Yu Qiang	CN103275949 (A)
Targeted enzymatic degradation of quorum-sensing peptides	The present invention generally relates to the fields of microbiology and wound care. More particularly, it concerns methods and compositions for inhibiting biofilms in wounds and on medical devices	2013	Alarcon Rodolfo; Mcnulty Amy K	US20130253382
Use of ellagitannins as inhibitors of bacterial quorum sensing	Materials and methods for the inhibition of bacterial QS are described. Methods of treating bacterial infections by administration of one or more ellagitannins in amounts effective for inhibiting bacterial QS are also provided	2013	Athee Kalai; Adonizio Allison L; Ausubel Frederick; Clardy Jon; Bennett Bradley; Downum Kelsey	US2013317094 (A1)
Use of hydroxytirosol and derivatives thereof as quorum quenchers	The quorum quenching activity of formula (I) or (II) compounds, such as hydroxytyrosol (HT), hydroxytyrosol acetate (HTA), 3,4-dihydroxyphenylacetic acid (DOPAC) and derivatives thereof are described	2013	Au Ón Calles David; Allende Prieto Ana; Fábregas Casal Jaime; Gómez-Acebo Gullón Eduardo	WO2014060581 (A1)
Use of the cect 7426 strain for generating quorum quenching of the autoinducer-2 signal (ai-2)	The invention relates to the use of a bacterial strain of the species Tenacibaculum discolor in the control of infectious diseases and for inhibiting biofilm formation caused by bacteria, through the inhibition of quorum sensing signals type AI -2. The invention applies to the field of molecular biology	2013	Otero Casal, Ana María; Romero Bernárdez Manuel	WO2014057151 (A1)