Patents on antivirulence therapies

Table 1 Patents concerning the inhibition of bacterial adhesion and colonization

Patent title	Description	Applicationdate	Inventors	Publicationnumber
Capsular polysaccharide adhesion antigen preparation, purification and use	General method for preparing pure capsular exopolysaccharide adhesins strains of adhesin coagulase-negative staphylococci to produce vaccines	1994	Pier Gerald B	US5980910 (A)
Method for inhibiting microbial adhesion on surfaces	A method for inhibiting microbial adhesion on surfaces in contact with an aqueous system is disclosed and involves adding a treatment comprising an alkyl sulfosuccinate surfactant to the system	1995	Wright J Barry; Michalopoulos Daniel L	US5512186
Method and apparatus for preventing adhesion and colonization of bacteria in medical devices	Activation of compounding photochemicals for preventing and eliminating adherence and colonization of bacteria	1996	Prescott Marvin A	WO9806340 (A1)
Decorin binding protein compositions and methods of use	DNA segments encoding these proteins and anti-(decorin binding protein) antibodies for use in the prevention of Borrelia colonization in an animal	1996	Guo Betty P; Hoeoek Magnus; Hanson Mark	WO9727301 (A1)
Collagen binding protein compositions and methods of use	Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aur. Also disclosed are Col Binding Protein (CBP) for use in the treatment of pathological infections, and in particular, for use in the prevention of bacterial adhesion to Col	1997	Hoeek Magnus; Patti Joseph M; House-Pompeo Karen; Sthanam Narayana; Symersky Jindrich	US6288214 (B1)
Surfactants for reducing bacterial adhesion onto surfaces	Inhibiting microbial colonization (ethylene oxide units) of a surface in contact with an aqueous system	1997	Donlan Rodney M; Elliot David L; Kapp Nancy J; Wiatr Christopher L; Rey Paula	US6039965 (A)
Composition of treatment of Candidiasis	Inhibition of adhesion of Candida colonization by using probiotics (Lactobacillus reuteri, Bifidobacterium infantis, Bifidobacterium lactis, Lactobacillus acidophilus not viable and non-viable Lactobacillus casei)	1998	Dohnlek Margaret H; Wagner Robert Doug; Balish Edward; Hilty Milo D	WO9917788 (A1)
Antimicrobial adhesion surface	The invention provides an implantable medical device with a hydrophilic coating to limit in vivo colonization of bacteria and fungi	1999	Zhong Samuel P	US6468649 (B1)
Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof	The invention relates to novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit	2000	Hultgren Scott J; Sauer Frederic G; Waksman Gabriel; Fuetterer Klaus; Choudhury Devapriya; Knight Stefan D; Barnhart Michelle	US7041465 (B1)
C3 binding polypeptide of Streptococcus agalactiae group b-Streptococcus	The invention involves the identification of a human complement C3 binding polypeptide and the nucleic acid that encodes the polypeptide from Streptococcus agalactiae	2000	Smith Beverly L; Ferrieri Patricia	US6582950 (B1)
Compounds directed against pilus biogenesis and activity in pathogenic bacteria, methods and compositions for synthesis thereof	Novel fluorinated linker compounds and methods of synthesis are provided. Methods for using the fluorinated linker compounds in methods of solid-phase synthesis of the N-substituted amino acid compounds are also disclosed (inhibiting or preventing the formation of a pilus chaperone-subunit complex)	2000	Kilhlberg Jan; Larsson Andreas; Svensson Anette; Fex Tomas; Hultgren Scott J; Pinkner Jerry	WO2001020995
DbpA compositions and methods of use	The DBP gene and decorin protein compositions of Borrelia burgdorferi are disclosed The DBP protein and antigenic epitopes derived from them are contemplated for use in preventing bacterial adhesion to decorin	2000	Guo Betty P; Hook Magnus	US6312907
Composition and method for controlling microbial adhesion and biofilm formation of surfaces	The invention describes how coating of surfaces with an extract, particularly a fish extract, can significantly reduce microbial adhesion, attachment, colonization and biofilm formation on surfaces	2003	Gram Lone Kirsten; Vogel Birtefonnesbech; Bagge-Ravn Dorthe	WO03092382 (A1)
Packaged antimicrobial medical device and method of preparing same	An antimicrobial suture assembly (halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof) to substantially inhibit bacterial colonization	2004	Scalzo Howard; Fischer Jerome A; Rothenburger Stephen	US2004220614 (A1)
Sealing material	A sealing material is presented (fluoropolymer layer, a reinforcing layer and an adhesive) to hinder growth and colonization of bacteria	2004	Patel Malay; Napolitano Michael; Hanrahan James R; Chu Chaokang	US2005250398 (A1)
Zn-releasing calcium phosphate (Zn-CaP) compounds for antimicrobial coating on orthodontic appliances and dental implants	Compositions of Zn-releasing calcium phosphate (Zn-CaP) compounds for use as anti-bacterial coatings for orthodontic brackets and dental implants	2006	Legeros Racquel Z; Legeros John P; Park Jae Hyun; Mijares Dindo	WO2007022211 (A2)
Composition for the administration of biologically active principles in gynaecological and rectal conditions and uses thereof	The invention relates to a composition for the administration of biologically active substances in gynaecological and rectal conditions, as well as the uses of said composition	2007	Strozzi Gianpaolo; Mogna Luca	US2010092440 (A1)
Enhanced treatments to kill or debilitate pathogenic microorganisms of a mammalian body	The novel treatments involve the use of anti-adhesive polysaccharide molecules to abolish or reduce the adhesion of Helicobacter pylori	2008	Nifantiev Nikolay; Wieland Gerhard D	US2011245198 (A1)
Non-leaching surface-active film compositions for microbial adhesion prevention	Coating (surfactant) useful to prevent bacterial colonization on a variety of surface including surfaces of medical devices	2008	Gruening Rainer; Qu Xin; Merritt Karen; Chen Paul N; Falevich Vitaly	MX2008009326 (A)
Prevention and treatment of Gram-negative, flagellated bacterial infections	EtpA which binds to the conserved region of the flagellin protein located at the tip of the flagella in Gram-negative bacteria (development vaccine)	2008	Fleckenstein James M	US2011206694 (A1)
Method for coating medical device1	Method for coating a medical device to prevent bacterial adhesion, colonization and device-associated infection (isocyanate-terminated polymer)	2010	Stopek Joshua	JP2011019902 (A)
Novel Enterococcus faecium LJS-01 and its use as a probiotic1	Enterococcus faecium LJS-01 shows good antimicrobial activity and strong capacity to adhere to intestinal epithelial cells	2010	Lin Chuen-FU; Wu Cheng-Nan; Lu Cheng-Hsiung; Hsu Wei-Li; Chiou Ming-Tang	TW201143631 (A)
Method for detecting colonization characteristic of lactobacillus in gastrointestinal tract on basis of green fluorescent protein1	The invention relates to a method for detecting the colonization characteristic of lactobacillus in the gastrointestinal tract on the basis of green fluorescent protein	2011	Yanping Wang; Jingrui Wang; Jinju Wang	CN102604877 (A)
Prevention of bacterial adhesion1	Prevention of adhesion of microorganisms on hard surfaces by the semi-permanent modification thereof during the cleaning process. A cleaning agent that contains surface-active polymers is used to prevent the bacterial colonization of hard surfaces	2011	Veith Birgit; Weide Mirko; Corbellini Francesca; Giesen Brigitte; Stumpe Stefan; Breves Roland; Barreleiro Paula; Karten Stefan; Bockmuehl Dirkl; Meier Frank	WO2012010700 (A1)
Pyruvate-ferredoxin oxidoreductase (PFO) adhesive protein as a target for inhibiting the adherence of Trichomonas vaginalis and as a diagnosis and vaccinal target for trichomoniasis1	Novel function of PFO upon participating in the cytoadherence of the Trichomonas vaginalis parasite to the hosting cell. The present invention enables development of vaccines for preventing the adhesion (and therefore the colonization) of parasites to the vaginal mucosa	2011	Verastegui Rossana Arroyo	MX2011011361 (A)
Vacuum assisted percutaneous appliance1	This device is stabilized by fibroblast in-growth and inhibits bacterial colonization	2012	Kantrowitz Allen B; Mortin Chris; Wadsworth JR Daniel C	US2013006186 (A1)

¹Those published from 2010 onwards are highlighted.