Pharmacophore approaches in protein kinase inhibitors design

Table 1 Protein kinases discussed in the review

Tyrosine protein kinases
Epidermal growth factor receptor (EGFR; Erb-1; HER1 in humans)	Receptor
Human epidermal growth factor receptor 2 (HER2; erbB2; protooncogene Neu)	Receptor
Vascular endothelial growth factor receptor 2	Receptor
Janus kinase 2	Non-receptor
Janus kinase 3	Non-receptor
Spleen tyrosine kinase	Non-receptor
Zeta-chain-associated protein kinase 70	Non-receptor
TEK tyrosine kinase, endothelial	Receptor
Serine/threonine protein kinases
Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Non-receptor
Cdc2-like kinase	Non-receptor
Checkpoint kinase 1	Non-receptor
Human inhibitor nuclear-factor κB kinase 2	Non-receptor
Cyclin-dependent kinase 1	Non-receptor
Cyclin-dependent kinase 2	Non-receptor
Polo-like kinase	Non-receptor
c-Jun N-terminal kinase 3	Non-receptor
Glycogen synthase kinase 3	Non-receptor
Mammalian target of rapamycin	Non-receptor
p38 mitogen-activated protein kinase	Non-receptor
Protein kinase B	Non-receptor