Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: Linking cardiometabolic and neuropsychiatric diseases

Table 1 Potential role of nerve growth factor and brain-derived neurotrophic factor in the pathogenesis and therapy of diseases

Neurological diseases	Alzheimer’s disease, mild cognitive impairment, Huntington’s disease, Parkinson’s disease, human immunodeficiency virus-associated dementia, amyothrophic lateral sclerosis, multiple sclerosis, epilepsy, Down syndrome, WAGRO syndrome (Wilms tumor, aniridia, mental retardation, genitourinary anomalies, obesity), cluster headache, diabetic neuropathy, diabetic retinopathy, diabetic erectile dysfunction
Psychiatric diseases	Depression, schizophrenia, eating disorders (anorexia nervosa; bulimia nervosa), pervasive developmental disorders (Autism, Rett syndrome, Fragile X syndrome)
Cardiometabolic diseases	Atherosclerosis, hypertension, obesity, type 2 diabetes mellitus, metabolic syndrome, heart failure, myocardial infarction, sudden cardiac death in diabetes mellitus (silent myocardial ischemia in diabetes mellitus), Kawasaki disease
Ocular diseases1	Glaucoma, retinitis pigmentosa, diabetic retinopathy, peripheral ulcerative keratopathy, dry eye
Skin diseases1	Diabetic wounds, pressure ulcers, chronic vasculitic ulcers
Malignant diseases1	Prostate cancer, breast cancer, melanoma
Urinary system diseases1	Overactive bladder syndrome, benign prostatic hyperplasia
Chronic pain-associated disorders1	Osteoarthritis, low back or spinal injuries, cancer, urological chronic pelvic pain syndromes

¹For references see[17].