Aryl hydrocarbon receptor as a new therapeutic target for cancer and immune disorders

Table 2 Degenerative diseases modified by aryl hydrocarbon receptor

Degenerative disease	AhR-dependent effect	Ref.
Experimental autoimmune encephalomyelitis	TCDD suppresses the disease by inducing T reg cells FICZ exacerbates the disease	[58]
GVHD	TCDD prevents the disease by generating T reg cells	[46]
Colitis	FICZ exacerbates disease	[77]
Collagen-induced arthritis	AhR exacerbates the diseas	[78]
Autoimmune uveoretinitis	TCDD suppresses the disease	[79]
Spontaneous autoimmune diabetes	TCDD suppresses the disease	[80]
Experimental multiple sclerosis	AhR activation reduces inflammation via Tr1 induction	[72]
Experimental lupus	Induction of Tr1 by AhR activation stops the inflammatory process	[81]
Rheumatoid arthritis	AhR activation by TCDD exacerbates the disease	[82]

AhR: Aryl hydrocarbon receptor; TCDD: 2,3,7,8-tetrachlorodibenzo-p-dioxin.