Copyright
©The Author(s) 2023.
World J Pharmacol. Dec 22, 2023; 12(4): 35-52
Published online Dec 22, 2023. doi: 10.5497/wjp.v12.i4.35
Published online Dec 22, 2023. doi: 10.5497/wjp.v12.i4.35
Table 7 Predicted biological activity of isothiocyanates derived from essential oils of the genus Capparis
| No | Anticancer properties. Pa1 | Anti-infectives properties. Pa1 |
| 1 | Apoptosis agonist (0.963) | Anti-schistosomal (0.759) |
| Chemoprotective (0.871) | Antiviral (arbovirus) (0.638) | |
| Antineoplastic (0.794) | Anti-seborrheic (0.614) | |
| 2 | Apoptosis agonist (0.965) | Anti-Helicobacter pylori (0.853) |
| Chemoprotective (0.890) | Anti-seborrheic (0.749) | |
| Chemosensitizer (0.798) | Anti-schistosomal (0.711) | |
| Antineoplastic (0.789) | Antiparasitic (0.537) | |
| 3 | Apoptosis agonist (0.956) | Anti-Helicobacter pylori (0.816) |
| Chemoprotective (0.866) | Anti-seborrheic (0.690) | |
| Chemosensitizer (0.779) | Antiviral (arbovirus) (0.635) | |
| Antineoplastic (0.743) | Anti-schistosomal (0.612) | |
| 4 | Apoptosis agonist (0.914) | Anti-Helicobacter pylori (0.720) |
| Chemoprotective (0.819) | Anti-schistosomal (0.687) | |
| Chemosensitizer (0.726) | Anti-seborrheic (0.684) | |
| 5 | Apoptosis agonist (0.956) | Anti-Helicobacter pylori (0.816) |
| Chemoprotective (0.858) | Antiviral (arbovirus) (0.690) | |
| Chemosensitizer (0.778) | Anti-schistosomal (0.594) | |
| Antineoplastic (0.751) | Antiparasitic (0.570) | |
| 6 | Apoptosis agonist (0.951) | Anti-Helicobacter pylori (0.804) |
| Chemoprotective (0.850) | Anti-seborrheic (0.731) | |
| Chemosensitizer (0.765) | Anti-schistosomal (0.665) | |
| Antineoplastic (0.720) | Antiparasitic (0.524) | |
| 7 | Apoptosis agonist (0.867) | Antiviral (arbovirus) (0.654) |
| Chemoprotective (0.782) | Anti-seborrheic (0.650) | |
| Chemosensitizer (0.694) | Anti-Helicobacter pylori (0.624) | |
| 8 | Apoptosis agonist (0.955) | Anti-Helicobacter pylori (0.822) |
| Chemoprotective (0.839) | Antiparasitic (0.680) | |
| Antineoplastic (0.833) | Anti-helmintic (0.632) | |
| Chemosensitizer (0.791) | Antifungal (0.568) | |
| 9 | Apoptosis agonist (0.965) | Anti-Helicobacter pylori (0.629) |
| Antineoplastic (0.825) | Anti-schistosomal (0.598) | |
| Chemoprotective (0.782) | ||
| Chemosensitizer (0.696) | ||
| 10 | Apoptosis agonist (0.933) | Anti-Helicobacter pylori (0.739) |
| Chemoprotective (0.847) | ||
| Antineoplastic (0.728) | ||
| Chemosensitizer (0.722) | ||
| 11 | Apoptosis agonist (0.884) | Anti-Helicobacter pylori (0.679) |
| Chemoprotective (0.812) | ||
| Antineoplastic (0.714) | ||
| Chemosensitizer (0.661) | ||
| 12 | Apoptosis agonist (0.956) | Anti-Helicobacter pylori (0.703) |
| Chemoprotective (0.825) | ||
| Chemosensitizer (0.741) | ||
| Antineoplastic (0.740) | ||
| Antineoplastic (genitourinary cancer) (0.581) | ||
| 13 | Apoptosis agonist (0.856) | Anti-Helicobacter pylori (0.703) |
| Chemoprotective (0.825) | ||
| Chemosensitizer (0.741) | ||
| Antineoplastic (0.740) | ||
| Antineoplastic (genitourinary cancer) (0.581) | ||
| 14 | Apoptosis agonist (0.959) | Anti-Helicobacter pylori (0.792) |
| Chemoprotective (0.867) | Antiparasitic (0.609) | |
| Chemosensitizer (0.787) | Anti-helmintic (0.581) | |
| Antineoplastic (0.775) | Antis-chistosomal (0.574) | |
| 15 | Apoptosis agonist (0.923) | Anti-Helicobacter pylori (0.659) |
| Chemoprotective (0.817) | Antifungal (0.658) | |
| Antineoplastic (0.771) | Antiparasitic (0.560) | |
| Chemosensitizer (0.728) | ||
| 16 | Apoptosis agonist (0.919) | Anti-Helicobacter pylori (0.752) |
| Chemoprotective (0.821) | Antiviral (arbovirus) (0.730) | |
| Antineoplastic (0.751) | Antifungal (0.678) | |
| Chemosensitizer (0.747) | Antiparasitic (0.672) | |
| 17 | Apoptosis agonist (0.953) | Anti-Helicobacter pylori (0.753) |
| Chemoprotective (0.830) | Antifungal (0.533) | |
| Antineoplastic (0.781) | ||
| Chemosensitizer (0.754) | ||
| 18 | Antineoplastic (myeloid leukemia) (0.805) | Anti-eczematic (0.606) |
| Chemosensitizer (0.742) | ||
| 19 | Apoptosis agonist (0.952) | Anti-Helicobacter pylori (0.769) |
| Chemoprotective (0.847) | Anti-eczematic (0.610) | |
| Chemosensitizer (0.764) | Antifungal (0.575) | |
| Antineoplastic (0.753) | Anti-schistosomal (0.502) | |
| 20 | Apoptosis agonist (0.955) | Anti-Helicobacter pylori (0.901) |
| Chemoprotective (0.911) | Anti-ulcerative (0.611) | |
| Antineoplastic (0.781) | ||
| Chemosensitizer (0.694) | ||
| Anticarcinogenic (0.573) | ||
| Chemopreventive (0.559) | ||
| 21 | Apoptosis agonist (0.851) | Anti-Helicobacter pylori (0.691) |
| Chemoprotective (0.839) | ||
| Chemosensitizer (0.747) | ||
| Antineoplastic (0.733) | ||
| Antineoplastic (genitourinary cancer) (0.627) | ||
| 22 | Apoptosis agonist (0.951) | Anti-seborrheic (0.775) |
| Antineoplastic (0.820) | Antifungal (0.543) | |
| Chemoprotective (0.752) | Anti-Helicobacter pylori (0.542) | |
| Chemosensitizer (0.673) | ||
| Preneoplastic conditions treatment (0.559) | ||
| 23 | Apoptosis agonist (0.929) | Anti-Helicobacter pylori (0.780) |
| Chemoprotective (0.832) | Antiviral (arbovirus) (0.626) | |
| Chemosensitizer (0.771) | Antiparasitic (0.589) | |
| Antineoplastic (0.762) | Anti-helmintic (0.559) | |
| Preneoplastic conditions treatment (0.515) | ||
| 24 | Apoptosis agonist (0.932) | Anti-Helicobacter pylori (0.736) |
| Chemoprotective (0.819) | Anti-schistosomal (0.579) | |
| Chemosensitizer (0.742) | Antifungal (0.550) | |
| Antineoplastic (0.675) | Antiviral (arbovirus) (0.531) | |
| Preneoplastic conditions treatment (0.541) | Antiparasitic (0.529) | |
| 25 | Apoptosis agonist (0.930) | Anti-Helicobacter pylori (0.715) |
| Chemoprotective (0.828) | Antiviral (arbovirus) (0.639) | |
| Antineoplastic (0.792) | Antifungal (0.620) | |
| Chemosensitizer (0.754) | ||
| 26 | Apoptosis agonist (0.938) | Periodontitis treatment (0.752) |
| Chemoprotective (0.827) | Anti-Helicobacter pylori (0.739) | |
| Antineoplastic (0.740) | Antifungal (0.622) | |
| Chemosensitizer (0.736) | Antiviral (arbovirus) (0.599) | |
| Preneoplastic conditions treatment (0.593) | ||
| 27 | Apoptosis agonist (0.937) | Periodontitis treatment (0.727) |
| Chemoprotective (0.820) | Anti-Helicobacter pylori (0.718) | |
| Antineoplastic (0.742) | Antifungal (0.644) | |
| Chemosensitizer (0.728) | Antiviral (arbovirus) (0.563) | |
| Preneoplastic conditions treatment (0.563) | ||
| 28 | Apoptosis agonist (0.934) | Periodontitis treatment (0.751) |
| Chemoprotective (0.823) | Anti-Helicobacter pylori (0.733) | |
| Antineoplastic (0.740) | Antifungal (0.639) | |
| Chemosensitizer (0.732) | Antiviral (arbovirus) (0.621) | |
| Preneoplastic conditions treatment (0.613) |
- Citation: Hanuš L, Naor T, Gloriozova T, Dembitsky VM. Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor drugs. World J Pharmacol 2023; 12(4): 35-52
- URL: https://www.wjgnet.com/2220-3192/full/v12/i4/35.htm
- DOI: https://dx.doi.org/10.5497/wjp.v12.i4.35