Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole

doi:10.5497/wjp.v12.i1.1

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Feb 17, 2023 (publication date) through Nov 7, 2024

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World Journal of Pharmacology

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2220-3192

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

World J Pharmacol. Feb 17, 2023; 12(1): 1-11
Published online Feb 17, 2023. doi: 10.5497/wjp.v12.i1.1

Table 3 Mean pharmacokinetic parameters for test and reference product (R1 and R2) for hydroxyitraconazole

Variable	mean ± SD
Variable	Test	Reference (R1)	Reference (R2)
C_max(ng/mL)	181.35 (58.30)	310.20 (11.63)	197.12 (56.84)
T_max	12	8	12
Kel	0.050 (0.015)	0.043 (0.014)	0.050 (0.019)
t_1/2	15.20 (4.92)	18.14 (7.10)	16.01 (6.55)
Residual area	2.72 (3.12)	4.31 (5.03)	3.37 (3.88)

SD: Standard deviation; T_max: Time to peak drug concentration; C_max: maximum concentration.

Citation: Naqvi SMH, Gala MYN, Muchhala S, Arumugam A, Panigrahi D, Patil D, Rathod R, Mane A. Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole. World J Pharmacol 2023; 12(1): 1-11
URL: https://www.wjgnet.com/2220-3192/full/v12/i1/1.htm
DOI: https://dx.doi.org/10.5497/wjp.v12.i1.1