Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole

doi:10.5497/wjp.v12.i1.1

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5363)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-3) series.

Item

Count

PDF

157

WORD

HTML

3157

Figures (1-3)

120

Tables (1-3)

121

Sum=3595

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

298

Download

1012

Sum=1310

Publishing Process of This Article

Item

Count

Browse

137

Download

321

Sum=458

Feb 17, 2023 (publication date) through Jul 17, 2024

Times Cited of This Article

Times Cited (1)

Journal Information of This Article

Publication Name

World Journal of Pharmacology

ISSN

2220-3192

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

World J Pharmacol. Feb 17, 2023; 12(1): 1-11
Published online Feb 17, 2023. doi: 10.5497/wjp.v12.i1.1

Table 2 Mean pharmacokinetic parameters for test and reference product (R1 and R2) for itraconazole

Variable	mean ± SD
Variable	Test (T)	Reference (R1)	Reference (R2)
C_max (ng/mL)	132.12 (65.31)	308.57 (173.63)	136.90 (67.91)
AUC_0-t	2738.083 (1164.121)	4953.205 (2472.121)	3065.766 (1295.989)
AUC_0-inf	3109.578 (1342.394)	5744.760 (2917.508)	3614.170 (1850.356)
T_max	11.45(6.05)	6.00 (1.49)	10.85 (6.33)
Kel	0.022 (0.007)	0.021 (0.007)	0.023 (0.008)
t_1/2	34.89 (13.18)	37.83 (14.95)	35.16 (20.14)
Residual area	11.92 (7.41)	12.86 (7.86)	12.22 (9.10)

SD: Standard deviation; AUC_0-t: Area under the concentration-time curve over the dosing interval; AUC_0-inf: Area under the curve; C_max: maximum concentration; T_max: Time to peak drug concentration.

Citation: Naqvi SMH, Gala MYN, Muchhala S, Arumugam A, Panigrahi D, Patil D, Rathod R, Mane A. Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole. World J Pharmacol 2023; 12(1): 1-11
URL: https://www.wjgnet.com/2220-3192/full/v12/i1/1.htm
DOI: https://dx.doi.org/10.5497/wjp.v12.i1.1