Antibiotic residues in milk and milk products: A momentous challenge for the pharmaceutical industry and medicine

Table 4 Tetracycline degradation constant rate k values at different temperatures[10]

Time in h	4 °C	37 °C	70 °C	100 °C
1	20 ± 4a	50 ± 6a	30 ± 6a	60 ± 15a
3	256 ± 32e	400 ± 46e	630 ± 81e	860 ± 61e
6	163 ± 17cd	290± 23cd	360 ± 17cd	510 ± 46d
12	116 ± 26c	225 ± 12c	300 ± 26c	340 ± 32c
24	50 ± 8b	135 ± 20b	160 ±18b	160 ± 02b

^aDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard deviation of triplicate samples.

^bDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard deviation of triplicate samples.

^cDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard deviation of triplicate samples.

^dDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard deviation of triplicate samples.

^eDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard deviation of triplicate samples.