Antibiotic residues in milk and milk products: A momentous challenge for the pharmaceutical industry and medicine

Table 3 Azithromycin degradation constant rate k values at different temperatures[10]

Time in h	4 °C	37 °C	70 °C	100 °C
1	1000 ± 8e	50 ± 1a	50 ± 2a	200 ± 3a
3	333 ± 3d	966 ± 9d	4033 ± 22e	3900 ± 18e
6	250 ± 2c	933 ± 8d	2000 ± 15d	2033 ± 16d
12	116 ± 2b	516 ± 7c	1025 ± 8c	1000 ± 6c
24	62 ± 2a	270 ± 4b	537 ± 5b	533 ± 4b

^aDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard error of triplicate samples.

^bDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard error of triplicate samples.

^cDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard error of triplicate samples.

^dDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard error of triplicate samples.

^eDifferent letters indicate statistically significant differences at P < 0.05 according to a Turkey’s honest significant difference post hoc test. Values are mean ± standard error of triplicate samples.