Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: Highlighting effects on behaviour, oxidative stress, and neuroinflammation

Figure 9 Effect of silymarin on histomorphology of the dentate gyrus of the hippocampus. Photomicrographs show small pyramidal cells, small granule cells within the dentate gyrus proper, and neuroglia scattered within the molecular layer. A: Vehicle; B: Sertraline; C: Silymarin at 140mg/kg of food; D: Silymarin at 280 mg/kg of food E: Dexamethasone; F: Dexamethasone and sertraline; G: Dexamethasone and silymarin at 140; H: Dexamethasone and silymarin at 280; I: Dexamethasone, sertraline and silymarin at 140; J: Dexamethasone, sertraline and silymarin at 280. Gc: Granule cells; Pc: Pyramidal cells; Ng: Neuroglia; ML: Molecular layer. Number of mice per treatment group = 5.