Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: Highlighting effects on behaviour, oxidative stress, and neuroinflammation

Figure 8 Effect of silymarin on histomorphology of the cerebral cortex. Photomicrographs show pyramidal cells, granule cells, and neuroglia. A: Vehicle; B: Sertraline C: Silymarin at 140mg/kg of food; D: Silymarin at 280 mg/kg of food; E: Dexamethasone, F: Dexamethasone and sertraline G: Dexamethasone and silymarin at 140; H: Dexamethasone and silymarin at 280; I: Dexamethasone, sertraline and silymarin at 140; J: Dexamethasone, sertraline and silymarin at 280. de-Pc: Degenerating pyramidal cells; de- Gc: Degenerating granule cells; de-Ng: Degenerating neuroglia; Gc: Granule cells; Pc: Pyramidal cells; Ng: Neuroglia. Number of mice per treatment group = 5.