Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: Highlighting effects on behaviour, oxidative stress, and neuroinflammation

Table 1 Serum antioxidant status and lipid peroxidation level

Group	SOD (U/mL)	CAT (U/mL)	GSH nmol/mL	GPx IU/L	MDA μmol/L
Control	0.92 ± 0.02	23.12 ± 0.21	0.73 ± 0.10	11.68 ± 1.10	6.42 ± 0.02
SERT	0.93 ± 0.02	21.11 ± 0.20	0.70 ± 0.11	10.60 ± 2.01	5.40 ± 0.02
SILY 140	1.54 ± 0.11a,b	28.72 ± 0.23a,b	0.82 ± 0.05a,b	24.54 ± 0.34a,b	3.38 ± 0.04a
SILY 280	1.98 ± 0.02a,b	31.76 ± 0.22a,b	1.12 ± 0.05a,b	30.20 ± 0.78a,b	2.33 ± 0.03a,b
DEX	0.78 ± 0.03a	12.78 ± 0.22a	0.30 ± 0.05a	6.65 ± 1.10a	14.40 ± 0.06a
DEX/SERT	0.67 ± 0.01a,c	13.67 ± 0.20a	0.35 ± 0.01a,c	6.92 ± 1.00c	14.57 ± 0.16a
DEX/SILY 140	0.98 ± 0.01c,d	22.16 ± 0.10c,d	0.56 ± 0.04a,c	11.40 ± 1.23c,d	9.65 ± 0.05a,c,d
DEX/SILY 280	1.00 ± 0.12a,c,d	27.20 ± 0.22a,c,d	0.78 ± 0.03a,c,d	12.45 ± 1.30c,d	5.57 ± 0.01a,c,d
DEX/SERT/SILY 140	0.82 ± 0.02a,c,d	19.70 ± 0.10a,c,d	0.75 ± 0.01c,d	10.12 ± 1.01c,d	4.98 ± 0.05a,c,d
DEX/SERT/SILY 280	0.98 ± 0.02a,c,d	21.21 ± 0.20c,d	0.88 ± 0.03a,c,d	11.32 ± 0.76c,d	4.82 ± 0.02a,c,d

Values are expressed as the mean ± SEM.

^aP < 0.05 vs control.

^bP < 0.05 vs SERT.

^cP < 0.05 vs DEX.

^dP < 0.05 vs DEX/SERT. SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; SERT: Sertraline; DEX: Dexamethasone; SILY: Silymarin. Number of mice per treatment.