Genome variation in the trophoblast cell lifespan: Diploidy, polyteny, depolytenization, genome segregation

Figure 3 Fragmentation of the rat trophoblast giant cells. A and B: First the giant nuclei fall into two large nuclei, the latter then breaks down into numerous small fragments (Fr); B: The giant nucleolus falls down into several nucleoli (Nl), then they form small nucleoli that seem to move into small nuclear fragments, some nucleoli in the nuclear fragments may be formed de novo. Heidenhain hematoxylin staining.