Structure-function relationship in viral RNA genomes: The case of hepatitis C virus

Figure 2 Secondary structure proposed for the hepatitis C virus internal ribosome entry site. The 5’ untranslatable region (UTR) plus domains V and VI located at the core coding sequence are included. Minimum region for internal ribosome entry site (IRES) activity is depicted. Domains involved in the interaction with eIF3 factor and ribosomal subunit 40S are marked in boxes. Pseudoknot elements are indicated as PK1 and PK2. The translation start codon is shown in bold. Nucleotide numbering corresponds to hepatitis C virus con1 isolate.