Regulation of the cell fate by DNA damage and hypoxia

doi:10.5496/wjmg.v3.i4.34

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Nov 27, 2013 (publication date) through Jul 25, 2024

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World Journal of Medical Genetics

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2220-3184

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Med Genet. Nov 27, 2013; 3(4): 34-40
Published online Nov 27, 2013. doi: 10.5496/wjmg.v3.i4.34

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Figure 2 p300/CBP associated factor determines cellular energy metabolism pathways under diverse types of stress. Differential post-translational modifications of p53 and hypoxia inducible factor 1α (HIF-1α) mediated by p300/CBP associated factor (PCAF), distinctly modulate cellular energy metabolism pathways by activating or repressing the expression of their target genes Tp53 induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2). PFK: Phosphofructokinase.

Citation: Rajendran R, Krstic-Demonacos M, Demonacos C. Regulation of the cell fate by DNA damage and hypoxia. World J Med Genet 2013; 3(4): 34-40
URL: https://www.wjgnet.com/2220-3184/full/v3/i4/34.htm
DOI: https://dx.doi.org/10.5496/wjmg.v3.i4.34