Regulation of the cell fate by DNA damage and hypoxia

Figure 1 p300/CBP associated factor mediates p53 and hypoxia inducible factor-1α transcription target selectivity in a manner dependent on the type of stress. In DNA damage conditions the p300/CBP associated factor (PCAF) is recruited to the promoters of pro-apoptotic gene targets thus inducing p53 mediated cell death, whereas in conditions of low oxygen availability PCAF mediates p53 and hypoxia inducible factor 1α (HIF-1α) post-translational modifications that selectively target both transcription factors to a subset of their transcription target genes with pro-survival activity thereby inducing cell proliferation.