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©The Author(s) 2022.
World J Med Genet. Oct 27, 2022; 10(2): 7-21
Published online Oct 27, 2022. doi: 10.5496/wjmg.v10.i2.7
Published online Oct 27, 2022. doi: 10.5496/wjmg.v10.i2.7
Table 1 Mechanistic links between epigenetic disruptions and infertility
| Epigenetic mechanisms | Links (Pathophysiology) | Ref. |
| DNA methylation | Hypermethylation or hypomethylation disrupts genomic imprinting and parental epigenetic mark erasure, resulting in abnormal expression of some genes and imprinted genes involved in gametogenesis and embryogenesis | [3,4,12,13,17,20,25,29-42,44-49] |
| Histone post-translational modification | Abnormal histone modification alters the expression of certain genes important in gametogenesis and embryogenesis. Also, it disrupts sperm DNA protamination, causing sperm abnormalities | [7,43,56-63] |
| miRNA | Up-regulation or down-regulation alters the expression of certain genes important in gametogenesis and embryogenesis | [15,68-75] |
- Citation: Yahaya TO, Bashar DM, Oladele EO, Umar J, Anyebe D, Izuafa A. Epigenetics in the etiology and management of infertility. World J Med Genet 2022; 10(2): 7-21
- URL: https://www.wjgnet.com/2220-3184/full/v10/i2/7.htm
- DOI: https://dx.doi.org/10.5496/wjmg.v10.i2.7